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dc.creatorBrailoiu, Eugen
dc.creatorDeliu, Elena
dc.creatorSporici, Romeo A.
dc.creatorBrailoiu, G. Cristina
dc.identifier.citationBrailoiu, E., Deliu, E., Sporici, R. A., Cristina Brailoiu, G., Irisin evokes bradycardia by activating cardiac-projecting neurons of nucleus ambiguus, Physiol Rep, 3 ( 6), 2015, e12419, doi: 10.14814/phy2.12419
dc.description.abstractIrisin is a newly identified hormone induced in muscle and adipose tissues by physical activity. This protein and its encoding gene have been identified in the brain; in addition, the precursor for irisin, FNDC5, can cross the blood-brain barrier. The fact that irisin is secreted during exercise together with the lower resting heart rate in athletes prompted us to investigate the effect of irisin on cardiac-projecting vagal neurons of nucleus ambiguus, a key regulatory site of heart rate. In vitro experiments in cultured nucleus ambiguus neurons indicate that irisin activates these neurons, inducing an increase in cytosolic Ca2+ concentration and neuronal depolarization. In vivo microinjection of irisin into the nucleus ambiguus promotes bradycardia in conscious rats. Our study is the first to report the effects of irisin on the neurons controlling the cardiac vagal tone and to link a myokine to a cardioprotective role, by modulating central cardiovascular regulation.
dc.format.extent8 pages
dc.relation.ispartofFaculty/ Researcher Works
dc.relation.haspartPhysiological Reports, Vol. 3, Iss. 6
dc.relation.isreferencedbyWiley Open Access
dc.rightsAttribution CC BY
dc.subjectAutonomic cardiovascular regulation
dc.subjectCytostolic CA2+
dc.subjectMembrane potential
dc.subjectVagal tone
dc.titleIrisin evokes bradycardia by activating cardiac-projecting neurons of nucleus ambiguus
dc.type.genreJournal article
dc.contributor.groupCenter for Substance Abuse Research (Temple University)
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact
dc.description.schoolcollegeLewis Katz School of Medicine
dc.temple.creatorBrailoiu, Eugen
dc.temple.creatorDeliu, Elena

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