Show simple item record

dc.creatorOhtake, Yosuke
dc.creatorSaito, Atsushi
dc.creatorLi, Shuxin
dc.date.accessioned2023-06-22T15:11:19Z
dc.date.available2023-06-22T15:11:19Z
dc.date.issued2018-02-03
dc.identifier.issn0014-4886
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/8681
dc.identifier.urihttp://hdl.handle.net/20.500.12613/8717
dc.description.abstractTyrosine phosphorylation is a common means of regulating protein functions and signal transduction in multiple cells. Protein tyrosine phosphatases (PTPs) are a large family of signaling enzymes that remove phosphate groups from tyrosine residues of target proteins and change their functions. Among them, receptor-type PTPs (RPTPs) exhibit a distinct spatial pattern of expression and play essential roles in regulating neurite outgrowth, axon guidance, and synaptic organization in developmental nervous system. Some RPTPs function as essential receptors for chondroitin sulfate proteoglycans that inhibit axon regeneration following CNS injury. Interestingly, certain RPTPs are also important to regulate functions of immune cells and development of autoimmune diseases. PTPσ, a RPTP in the LAR subfamily, is expressed in various immune cells and regulates their differentiation, production of various cytokines and immune responses. In this review, we highlight the physiological and pathological significance of PTPσ and related molecules in both nervous and immune systems.
dc.format.extent9 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofFaculty/ Researcher Works
dc.relation.haspartExperimental Neurology, Vol. 302
dc.relation.isreferencedbyElsevier
dc.rightsAttribution-NonCommercial-NoDerivs CC BY-NC-ND
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectProtein tyrosine phosphatase σ (PTPσ)
dc.subjectNeuroplasticity
dc.subjectChondroitin sulfate proteoglycan (CSPG) receptor
dc.subjectAxon regeneration
dc.subjectImmune cell
dc.subjectDendritic cell
dc.subjectT lymphocyte
dc.subjectMultiple sclerosis
dc.titleDiverse functions of protein tyrosine phosphatase σ in the nervous and immune systems
dc.typeText
dc.type.genreJournal article
dc.contributor.groupShriners Hospital Pediatric Research Center (Temple University)
dc.description.departmentAnatomy and Cell Biology
dc.relation.doihttps://doi.org/10.1016/j.expneurol.2018.01.014
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeLewis Katz School of Medicine
dc.temple.creatorLi, Shuxin
refterms.dateFOA2023-06-22T15:11:19Z


Files in this item

Thumbnail
Name:
Li-JournalArticle-2018.pdf
Size:
605.7Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs CC BY-NC-ND
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs CC BY-NC-ND