Identification of Novel Clinical Factors Associated with Hepatic Fat Accumulation in Extreme Obesity
Wood, G. Craig
Strodel, William E.
Gabrielsen, Jon D.
Still, Christopher D.
DiStefano, Johanna K.
DepartmentMedical Genetics and Molecular Biochemistry
Permanent link to this recordhttp://hdl.handle.net/20.500.12613/8695
MetadataShow full item record
AbstractObjectives. The accumulation of lipids stored as excess triglycerides in the liver (steatosis) is highly prevalent in obesity and has been associated with several clinical characteristics, but most studies have been based on relatively small sample sizes using a limited set of variables. We sought to identify clinical factors associated with liver fat accumulation in a large cohort of patients with extreme obesity. Methods. We analyzed 2929 patients undergoing intraoperative liver biopsy during a primary bariatric surgery. Univariate and multivariate regression modeling was used to identify associations with over 200 clinical variables with the presence of any fat in the liver and with moderate to severe versus mild fat accumulation. Results. A total of 19 data elements were associated with the presence of liver fat and 11 with severity of liver fat including ALT and AST, plasma lipid, glucose, and iron metabolism variables, several medications and laboratory measures, and sleep apnea. The accuracy of a multiple logistic regression model for presence of liver fat was 81% and for severity of liver fat accumulation was 77%. Conclusions. A limited set of clinical factors can be used to model hepatic fat accumulation with moderate accuracy and may provide potential mechanistic insights in the setting of extreme obesity.
CitationGlenn S. Gerhard, Peter Benotti, G. Craig Wood, Xin Chu, George Argyropoulos, Anthony Petrick, William E. Strodel, Jon D. Gabrielsen, Anna Ibele, Christopher D. Still, Christopher Kingsley, Johanna DiStefano, "Identification of Novel Clinical Factors Associated with Hepatic Fat Accumulation in Extreme Obesity", Journal of Obesity, vol. 2014, Article ID 368210, 8 pages, 2014. https://doi.org/10.1155/2014/368210
Citation to related workHindawi
Has partJournal of Obesity, Vol. 2014
ADA complianceFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact firstname.lastname@example.org