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dc.creatorChirico, Erica N.
dc.creatorDing, Dennis
dc.creatorMuthukumaran, Geetha
dc.creatorHouser, Steven
dc.creatorStarosta, Tim
dc.creatorMu, Anbin
dc.creatorMargulies, Kenneth B.
dc.creatorLibonati, Joseph R.
dc.date.accessioned2023-03-07T20:01:18Z
dc.date.available2023-03-07T20:01:18Z
dc.date.issued2015-10-20
dc.identifier.citationChirico, E. N., Ding, D., Muthukumaran, G., Houser, S. R., Starosta, T., Mu, A., Margulies, K. B., Libonati, J. R.. Acute aerobic exercise increases exogenously infused bone marrow cell retention in the heart. Physiol Rep, 3 ( 10), 2015, e12566, doi: 10.14814/phy2.12566
dc.identifier.issn2051-817X
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/8364
dc.identifier.urihttp://hdl.handle.net/20.500.12613/8397
dc.description.abstractStem cell therapy for myocardial infarction (MI) has been shown to improve cardiac function and reduce infarct size. Exercise training, in the form of cardiac rehabilitation, is an essential part of patient care post-MI. Hence, we tested the effects of acute and chronic aerobic exercise on stem cell retention and cardiac remodeling post-MI. Small epicardial MI's were induced in 12-month-old C57BL/6 mice via cryoinjury. Two weeks post-MI, vehicle infusion (N = 4) or GFP+ bone marrow-derived cells (BMC) were injected (tail vein I.V.) immediately after acute exercise (N = 14) or sedentary conditions (N = 14). A subset of mice continued a 5-week intervention of chronic treadmill exercise (10–13 m/min; 45 min/day; 4 days/week; N = 7) or remained sedentary (N = 6). Exercise tolerance was assessed using a graded exercise test, and cardiac function was assessed with echocardiography. Acute exercise increased GFP+ BMC retention in the infarcted zone of the heart by 30% versus sedentary (P < 0.05). This was not associated with alterations in myocardial function or gene expression of key cell adhesion molecules. Animals treated with chronic exercise increased exercise capacity (P < 0.05) and cardiac mass (P < 0.05) without change in left ventricular ejection fraction (LVEF), infarct size, or regional wall thickness (P = NS) compared with sedentary. While BMC's alone did not affect exercise capacity, they increased LVEF (P < 0.05) and Ki67+ nuclei number in the border zone of the heart (P < 0.05), which was potentiated with chronic exercise training (P < 0.05). We conclude that acute exercise increases BMC retention in infarcted hearts and chronic training increases exogenous BMC-mediated effects on stimulating the cardiomyocyte cell cycle. These preclinical results suggest that exercise may help to optimize stem cell therapeutics following MI.
dc.format.extent11 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofFaculty/ Researcher Works
dc.relation.haspartPhysiological Reports, Vol. 3, Iss. 10
dc.relation.isreferencedbyWiley Open Access
dc.rightsAttribution CC BY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAdult stem cells
dc.subjectCell adhesion molecules
dc.subjectMyocardial infarction
dc.titleAcute aerobic exercise increases exogenously infused bone marrow cell retention in the heart
dc.typeText
dc.type.genreJournal article
dc.description.departmentCardiovascular Sciences
dc.relation.doihttps://doi.org/10.14814/phy2.12566
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeLewis Katz School of Medicine
dc.creator.orcidHouser|0000-0001-6359-5425
dc.temple.creatorHouser, Steven R.
dc.temple.creatorStarosta, Tim
refterms.dateFOA2023-03-07T20:01:18Z


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