Falling down the biological rabbit hole: Epstein-Barr virus, biography, and multiple sclerosis
AuthorHorwitz, Ralph I.
Singer, Burton H.
Cullen, Mark R.
Geography and Urban Studies
Permanent link to this recordhttp://hdl.handle.net/20.500.12613/8254
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AbstractA recent research report in Science by Bjornevik et al. tested the hypothesis that multiple sclerosis (MS) is caused by Epstein-Barr virus (EBV) in a cohort of more than ten million adults on active duty in the US military during a 20-year period (1993–2013) (1). The authors reported that individuals who had prior EBV infection were 24 times more likely to develop MS than noninfected persons. The findings appear to confirm a longstanding suspicion linking EBV to MS and led many to call for an EBV vaccine to prevent MS. A closer examination of the article, however, indicates the analysis was incomplete and misrepresents the data. In fact, a strong association between EBV and MS was present only for those with recent infection occurring during active-duty military service.
Citation to related workAmerican Society for Clinical Investigation
Has partThe Journal of Clinical Investigation, Vol. 132, No. 17
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