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dc.creatorChen, Judy
dc.creatorDeng, Jane C.
dc.creatorZemans, Rachel L.
dc.creatorBahmed, Karim
dc.creatorKosmider, Beata
dc.creatorZhang, Min
dc.creatorPeters-Golden, Marc
dc.creatorGoldstein, Daniel R.
dc.date.accessioned2023-01-06T17:20:44Z
dc.date.available2023-01-06T17:20:44Z
dc.date.issued2022-11-09
dc.identifier.citationChen, J., Deng, J.C., Zemans, R.L. et al. Age-induced prostaglandin E2 impairs mitochondrial fitness and increases mortality to influenza infection. Nat Commun 13, 6759 (2022). https://doi.org/10.1038/s41467-022-34593-y
dc.identifier.issn2041-1723
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/8203
dc.identifier.urihttp://hdl.handle.net/20.500.12613/8232
dc.description.abstractAging impairs the immune responses to influenza A virus (IAV), resulting in increased mortality to IAV infections in older adults. However, the factors within the aged lung that compromise host defense to IAV remain unknown. Using a murine model and human samples, we identified prostaglandin E2 (PGE2), as such a factor. Senescent type II alveolar epithelial cells (AECs) are overproducers of PGE2 within the aged lung. PGE2 impairs the proliferation of alveolar macrophages (AMs), critical cells for defense against respiratory pathogens, via reduction of oxidative phosphorylation and mitophagy. Importantly, blockade of the PGE2 receptor EP2 in aged mice improves AM mitochondrial function, increases AM numbers and enhances survival to IAV infection. In conclusion, our study reveals a key mechanism that compromises host defense to IAV, and possibly other respiratory infections, with aging and suggests potential new therapeutic or preventative avenues to protect against viral respiratory disease in older adults.
dc.format.extent15 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofFaculty/Researcher Works
dc.relation.haspartNature Communications, Vol. 13
dc.relation.isreferencedbyNature Research
dc.rightsAttribution CC BY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAgeing
dc.subjectInfection
dc.subjectInfluenza virus
dc.titleAge-induced prostaglandin E2 impairs mitochondrial fitness and increases mortality to influenza infection
dc.typeText
dc.type.genreJournal article
dc.contributor.groupCenter for Inflammation and Lung Research (Temple University)
dc.description.departmentThoracic Medicine and Surgery
dc.description.departmentMicrobiology, Immunology, and Inflammation
dc.relation.doihttps://doi.org/10.1038/s41467-022-34593-y
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeLewis Katz School of Medicine
dc.creator.orcidBahmed|0000-0001-9854-5452
dc.creator.orcidKosmider|0000-0001-7421-5424
dc.temple.creatorBahmed, Karim
dc.temple.creatorKosmider, Beata
refterms.dateFOA2023-01-06T17:20:44Z


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