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dc.creatorYeoh, Su-Ann
dc.creatorGianfrancesco, Milena
dc.creatorLawson-Tovey, Saskia
dc.creatorHyrich, Kimme L.
dc.creatorStrangfeld, Anja
dc.creatorGossec, Laure
dc.creatorCarmona, Loreto
dc.creatorMateus, Elsa F.
dc.creatorSchafer, Martin
dc.creatorRichez, Christophe
dc.creatorHachulla, Eric
dc.creatorHolmqvist, Marie
dc.creatorScire, Carlo Alberto
dc.creatorLorenz, Hanns-Martin
dc.creatorVoll, Reinhard E.
dc.creatorHasseli, Rebecca
dc.creatorJayatilleke, Arundathi
dc.creatorHsu, Tiffany Y-T.
dc.creatorD'Silva, Kristin M.
dc.creatorPimentel-Quiroz, Victor R.
dc.creatorVasquez del Mercado, Monica
dc.creatorKatsuyuki Shinjo, Samuel
dc.creatorTorres dos Reis Neto, Edgard
dc.creatorFerreira da Rocha Junior, Laurindo
dc.creatorde Oliveira e Silva Montana, Ana Carolina
dc.creatorPons-Estel, Guillermo J.
dc.creatorOrnella, Sofia
dc.creatorD'Angelo Exeni, Maria Eugenia
dc.creatorVelozo, Edson
dc.creatorJordan, Paula
dc.creatorSirotich, Emily
dc.creatorHausmann, Jonathan S.
dc.creatorLiew, Jean W.
dc.creatorJacobsohn, Lindsay
dc.creatorGore-Massy, Monique
dc.creatorSufka, Paul
dc.creatorGrainger, Rebecca
dc.creatorBhana, Suleman
dc.creatorWallace, Zachary
dc.creatorRobinson, Philip C.
dc.creatorYazdany, Jinoos
dc.creatorMachado, Pedro M.
dc.identifier.citationYeoh S, Gianfrancesco M, Lawson-Tovey S On behalf of the COVID-19 Global Rheumatology Alliance, et alFactors associated with severe COVID-19 in people with idiopathic inflammatory myopathy: results from the COVID-19 Global Rheumatology Alliance physician-reported registryRMD Open 2022;8:e002508. doi: 10.1136/rmdopen-2022-002508
dc.description.abstractObjectives: To investigate factors associated with severe COVID-19 in people with idiopathic inflammatory myopathy (IIM). Methods: Demographic data, clinical characteristics and COVID-19 outcome severity of adults with IIM were obtained from the COVID-19 Global Rheumatology Alliance physician-reported registry. A 3-point ordinal COVID-19 severity scale was defined: (1) no hospitalisation, (2) hospitalisation (and no death) and (3) death. ORs were estimated using multivariable ordinal logistic regression. Sensitivity analyses were performed using a 4-point ordinal scale: (1) no hospitalisation, (2) hospitalisation with no oxygen (and no death), (3) hospitalisation with oxygen/ventilation (and no death) and 4) death. Results: Of 348 patients, 48% were not hospitalised, 39% were hospitalised (and did not die) and 13% died. Older age (OR=1.59/decade, 95% CI 1.31 to 1.91), high disease activity (OR=3.50, 95% CI 1.25 to 9.83; vs remission), ≥2 comorbidities (OR=2.63, 95% CI 1.39 to 4.98; vs none), prednisolone-equivalent dose >7.5 mg/day (OR=2.40, 95% CI 1.09 to 5.28; vs no intake) and exposure to rituximab (OR=2.71, 95% CI 1.28 to 5.72; vs conventional synthetic disease-modifying antirheumatic drugs only) were independently associated with severe COVID-19. In addition to these variables, in the sensitivity analyses, male sex (OR range: 1.65–1.83; vs female) was also significantly associated with severe outcomes, while COVID-19 diagnosis after 1 October 2020 (OR range: 0.51–0.59; vs on/before 15 June 2020) was significantly associated with less severe outcomes, but these associations were not significant in the main model (OR=1.57, 95% CI 0.95 to 2.59; and OR=0.61, 95% CI 0.37 to 1.00; respectively). Conclusions: This is the first large registry data on outcomes of COVID-19 in people with IIM. Older age, male sex, higher comorbidity burden, high disease activity, prednisolone-equivalent dose >7.5 mg/day and rituximab exposure were associated with severe COVID-19. These findings will enable risk stratification and inform management decisions for patients with IIM.
dc.format.extent8 pages
dc.relation.ispartofCOVID-19 Research
dc.relation.haspartRMD Open, Vol. 8, Iss. 2
dc.relation.isreferencedbyBMJ Publishing Group
dc.rightsAttribution-NonCommercial CC BY-NC
dc.titleFactors associated with severe COVID-19 in people with idiopathic inflammatory myopathy: results from the COVID-19 Global Rheumatology Alliance physician-reported registry
dc.type.genreJournal article
dc.description.departmentSection of Rheumatology
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact
dc.description.schoolcollegeLewis Katz School of Medicine
dc.temple.creatorJayatilleke, Arundathi

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