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dc.creatorRossi, Elena
dc.creatorMutti, Luciano
dc.creatorMorrione, Andrea
dc.creatorGiordano, Antonio
dc.date.accessioned2022-12-20T19:23:36Z
dc.date.available2022-12-20T19:23:36Z
dc.date.issued2022-11-29
dc.identifier.citationRossi E, Mutti L, Morrione A, Giordano A. Neuro–Immune Interactions in Severe COVID-19 Infection. Pathogens. 2022; 11(11):1256. https://doi.org/10.3390/pathogens11111256
dc.identifier.issn2076-0817
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/8176
dc.identifier.urihttp://hdl.handle.net/20.500.12613/8205
dc.description.abstractSARS-CoV-2 is a new coronavirus that has affected the world since 2019. Interstitial pneumonia is the most common clinical presentation, but additional symptoms have been reported, including neurological manifestations. Severe forms of infection, especially in elderly patients, present as an excessive inflammatory response called “cytokine storm”, which can lead to acute respiratory distress syndrome (ARDS), multiorgan failure and death. Little is known about the relationship between symptoms and clinical outcomes or the characteristics of virus–host interactions. The aim of this narrative review is to highlight possible links between neurological involvement and respiratory damage mediated by pathological inflammatory pathways in SARS-CoV-2 infection. We will focus on neuro–immune interactions and age-related immunity decline and discuss some pathological mechanisms that contribute to negative outcomes in COVID-19 patients. Furthermore, we will describe available therapeutic strategies and their effects on COVID-19 neurological symptoms.
dc.format.extent27 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofCOVID-19 Research
dc.relation.haspartPathogens, Vol. 11, No. 11
dc.relation.isreferencedbyMDPI
dc.rightsAttribution CC BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectSevere COVID-19
dc.subjectNeurologic symptoms
dc.subjectRenin-angiotensin system
dc.subjectInflammatory responses
dc.subjectLymphopenia
dc.subjectNeuro–immune interactions
dc.subjectAging
dc.titleNeuro–Immune Interactions in Severe COVID-19 Infection
dc.typeText
dc.type.genreJournal article
dc.contributor.groupSbarro Institute for Cancer Research and Molecular Medicine (Temple University)
dc.contributor.groupCenter for Biotechnology (Temple University)
dc.description.departmentBiology
dc.relation.doihttps://doi.org/10.3390/pathogens11111256
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeTemple University. College of Science and Technology
dc.creator.orcidMutti|0000-0002-1578-2637
dc.creator.orcidMorrione|0000-0002-2319-7884
dc.creator.orcidGiordano|0000-0002-5959-016X
dc.temple.creatorMutti, Luciano
dc.temple.creatorMorrione, Andrea
dc.temple.creatorGiordano, Antonio
refterms.dateFOA2022-12-20T19:23:36Z


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