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dc.creatorAlapati, Deepthi
dc.creatorShaffer, Thomas
dc.date.accessioned2022-09-01T16:19:34Z
dc.date.available2022-09-01T16:19:34Z
dc.date.issued2022-05-10
dc.identifier.citationAlapati D and Shaffer TH (2022) Administration of Drugs/Gene Products to the Respiratory System: A Historical Perspective of the Use of Inert Liquids. Front. Physiol. 13:871893. doi: 10.3389/fphys.2022.871893
dc.identifier.issn1664-042X
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/8117
dc.identifier.urihttp://hdl.handle.net/20.500.12613/8145
dc.description.abstractThe present review is a historical perspective of methodology and applications using inert liquids for respiratory support and as a vehicle to deliver biological agents to the respiratory system. As such, the background of using oxygenated inert liquids (considered a drug when used in the lungs) opposed to an oxygen-nitrogen gas mixture for respiratory support is presented. The properties of these inert liquids and the mechanisms of gas exchange and lung function alterations using this technology are described. In addition, published preclinical and clinical trial results are discussed with respect to treatment modalities for respiratory diseases. Finally, this forward-looking review provides a comprehensive overview of potential methods for administration of drugs/gene products to the respiratory system and potential biomedical applications.
dc.format.extent10 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofFaculty/ Researcher Works
dc.relation.haspartFrontiers in Physiology, Vol. 13
dc.relation.isreferencedbyFrontiers Media
dc.rightsAttribution CC BY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectDrug delivery
dc.subjectGene delivery
dc.subjectPartial liquid ventilation
dc.subjectPerfluorochemicals
dc.subjectPulmonary
dc.titleAdministration of Drugs/Gene Products to the Respiratory System: A Historical Perspective of the Use of Inert Liquids
dc.typeText
dc.type.genreJournal article
dc.description.departmentPhysiology
dc.relation.doihttps://doi.org/10.3389/fphys.2022.871893
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeLewis Katz School of Medicine
dc.creator.orcidShaffer|0000-0003-1757-8506
dc.temple.creatorShaffer, Thomas H.
refterms.dateFOA2022-09-01T16:19:34Z


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