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dc.creatorPisani, David
dc.creatorCalleja-Agius, Jean
dc.creatorDI FIORE, Riccardo
dc.creatorO'Leary, John J.
dc.creatorBeirne, James J.
dc.creatorO'Toole, Sharon A.
dc.creatorFelix, Ana
dc.creatorSaid-Huntingford, Ian
dc.date.accessioned2022-09-01T16:19:25Z
dc.date.available2022-09-01T16:19:25Z
dc.date.issued2021-12-13
dc.identifier.citationPisani D, Calleja-Agius J, Di Fiore R, O’Leary JJ, Beirne JP, O’Toole SA, Felix A, Said-Huntingford I. Epithelioid Trophoblastic Tumour: A Case with Genetic Linkage to a Child Born over Seventeen Years Prior, Successfully Treated with Surgery and Pembrolizumab. Current Oncology. 2021; 28(6):5346-5355. https://doi.org/10.3390/curroncol28060446
dc.identifier.issn1718-7729
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/8086
dc.identifier.urihttp://hdl.handle.net/20.500.12613/8114
dc.description.abstractEpithelioid trophoblastic tumours are rare neoplasms showing differentiation towards the chorion leave-type intermediate cytotrophoblast, with only a handful of cases being reported in the literature. These tumours are slow-growing and are typically confined to the uterus for extended periods of time. While the pathogenesis is unclear, they are thought to arise from a remnant intermediate trophoblast originating from prior normal pregnancies or, less frequently, gestational trophoblastic tumours. A protracted time period between the gestational event and tumour development is typical. This case describes a 49-year-old previously healthy female who presented with a completely asymptomatic uterine mass, discovered incidentally during a routine gynaecological assessment. The pathological analysis of the hysterectomy specimen confirmed an epithelioid trophoblastic tumour, involving the uterus and cervix. This is a rare gynaecological tumour. A comparative short tandem repeat analysis revealed genetic similarities to a previous healthy gestation seventeen years prior. She was successful treated with adjuvant pembrolizumab, with no evidence of disease recurrence to date.
dc.format.extent10 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofFaculty/ Researcher Works
dc.relation.haspartCurrent Oncology, Vol. 28
dc.relation.isreferencedbyMDPI
dc.rightsAttribution CC BY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectEpithelioid trophoblastic tumour
dc.subjectGestational trophoblastic tumour
dc.subjectRare gynaecological tumour
dc.titleEpithelioid Trophoblastic Tumour: A Case with Genetic Linkage to a Child Born over Seventeen Years Prior, Successfully Treated with Surgery and Pembrolizumab
dc.typeText
dc.type.genreJournal article
dc.contributor.groupCenter for Biotechnology, Sbarro Institute for Cancer Research and Molecular Medicine (Temple University)
dc.relation.doihttps://doi.org/10.3390/curroncol28060446
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeTemple University. College of Science and Technology
dc.creator.orcidDi Fiore|0000-0003-4905-6948
dc.temple.creatorDi Fiore, Riccardo
refterms.dateFOA2022-09-01T16:19:25Z


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