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    Hippocampal Threat Reactivity Interacts with Physiological Arousal to Predict PTSD Symptoms

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    Murty-PostPrint-2021-04.pdf
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    Genre
    Post-print
    Date
    2021-05-10
    Author
    Tanriverdi, Busra
    Gregory, David F.
    Murty, Vishnu cc
    Department
    Psychology and Neuroscience
    Subject
    Arousal
    Fear-potentiated startle
    Hippocampus
    PTSD
    Threat
    Trauma
    Permanent link to this record
    http://hdl.handle.net/20.500.12613/7957
    
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    DOI
    https://doi.org/10.1523/JNEUROSCI.0911-21.2022
    Abstract
    Prior studies highlight how threat-related arousal may impair hippocampal function. Hippocampal impairments are reliably associated with post-traumatic stress disorder (PTSD); however, little research has characterized how increased threat-sensitivity may drive arousal responses to alter hippocampal reactivity, and further how these alterations relate to the sequelae of trauma-related symptoms. In a sample of individuals recently exposed to trauma (N=117, 76 Female), we found that PTSD symptoms at 2-weeks and 3-months were associated with decreased hippocampal responses to threat as assessed with functional magnetic resonance imaging (fMRI). Further, decreased hippocampal threat sensitivity was predicted by individual differences in fear-potentiated startle, an arousal-mediated behavior. Critically, the relationship between hippocampal threat sensitivity and PTSD symptomology only emerged in individuals who showed high threat-related arousal. Collectively, our finding suggests that development of PTSD is associated with threat-related decreases in hippocampal function, due to increases in fear-potentiated arousal.
    Citation
    Tanriverdi, B., Gregory, D. F., Ely, T. D., Harnett, N. G., van Rooij, S. J. H., Lebois, L., … Murty, V. P. (2022). Hippocampal Threat Reactivity Interacts with Physiological Arousal to Predict PTSD Symptoms. Journal of Neuroscience. https://doi.org/10.1523/JNEUROSCI.0911-21.2022
    Citation to related work
    Society for Neuroscience
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    Journal of Neuroscience
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    http://dx.doi.org/10.34944/dspace/7929
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