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dc.contributor.advisorQueisser, Gillian
dc.creatorBorole, Piyush
dc.date.accessioned2022-05-26T18:07:53Z
dc.date.available2022-05-26T18:07:53Z
dc.date.issued2022
dc.identifier.urihttp://hdl.handle.net/20.500.12613/7671
dc.description.abstractCalcium signaling has been identified with triggering of gene transcriptions associated with learning and neuroprotection in neurons. Studies indicate that dysregulation of calcium signaling is correlated with severe Alzheimer Disease pathologies. A stable calcium wave or signal arising from triggers in dendritic synapses needs to reach soma with constant amplitude for proper functioning of neurons. In this study, we introduce "CalciumSim", a calcium dynamics simulator which works on dimensionally reduced model. Numerical analysis is conducted to obtain the best configuration of neuron geometry to make the code efficient and fast. Alongside, biologically important insights are derived by modulating and changing parameters of the simulation. The ability of "CalciumSim" to work with real neuron geometries allows user to study calcium signalling in a realistic model.
dc.format.extent74 pages
dc.language.isoeng
dc.publisherTemple University. Libraries
dc.relation.ispartofTheses and Dissertations
dc.rightsIN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available.
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectApplied mathematics
dc.subjectCalcium modeling
dc.subjectCalcium pumps
dc.subjectDiffusion equations
dc.subjectMATLAB
dc.subjectNeurons
dc.subjectNumerical methods
dc.titleCalciumSim: Simulator for calcium dynamics on neuron graphs using dimensionally reduced model
dc.typeText
dc.type.genreThesis/Dissertation
dc.contributor.committeememberSeibold, Benjamin
dc.contributor.committeememberYilmaz, Atilla
dc.contributor.committeememberPicone, Joseph
dc.description.departmentMathematics
dc.relation.doihttp://dx.doi.org/10.34944/dspace/7643
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.degreeM.S.
dc.identifier.proqst14753
dc.creator.orcid0000-0003-3327-5847
dc.date.updated2022-05-11T16:08:15Z
refterms.dateFOA2022-05-26T18:07:54Z
dc.identifier.filenameBorole_temple_0225M_14753.pdf


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