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dc.creatorMaugeri, Grazia
dc.creatorD'Agata, Velia
dc.creatorTrovato, Bruno
dc.creatorRoggio, Federico
dc.creatorCastorina, Alessandro
dc.creatorVecchio, Michele
dc.creatorDi Rosa, Michelino
dc.creatorMusumeci, Giuseppe
dc.date.accessioned2022-04-29T19:21:44Z
dc.date.available2022-04-29T19:21:44Z
dc.date.issued2021-11-01
dc.identifier.issn2405-8440
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/7605
dc.identifier.urihttp://hdl.handle.net/20.500.12613/7627
dc.description.abstractPeripheral nerve injury is a complex condition with a variety of signs and symptoms depending on the severity and nerves involved. Peripheral nerve damage may lead to sensory and motor functions deficits and even lifelong disability, causing important socioeconomic costs worldwide. Despite the increase in knowledge of the mechanisms of injury and regeneration, a full functional recovery is still unsatisfying in the majority of patients. It is well known that exercise promotes physical and psychological well-being, by ameliorating general health. In the last years, there has been a growing interest in evaluating the effects of exercise on the peripheral nervous system. Experimental works with rodent models showed the potential utility of exercise following peripheral nerve injuries, as evinced by increasing axon regeneration, muscle reinnervation, better recovery of strength, muscle mass and higher expression of neurotrophic factors. Moreover, clinical evidence showed positive trends in favour of physical therapy following peripheral nerve damage based on the improvement of range of motion (ROM), muscle power grade and pain. After a brief overview of peripheral nerve anatomy and the different types of nerve injury, the present review aims to summarize the impact of exercise on peripheral nerve regeneration. Some clinical evidence regarding the effect of exercise after peripheral nerve injury will also be discussed.
dc.format.extent8 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofFaculty/ Researcher Works
dc.relation.haspartHeliyon, Vol. 7
dc.relation.isreferencedbyElsevier
dc.rightsAttribution-NonCommercial-NoDerivs CC BY-NC-ND
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectNerve injury
dc.subjectNerve regeneration
dc.subjectPhysical exercise
dc.subjectTherapeutic exercise
dc.titleThe role of exercise on peripheral nerve regeneration: from animal model to clinical application
dc.typeText
dc.type.genreJournal article
dc.contributor.groupSbarro Institute for Cancer Research and Molecular Medicine (Temple University)
dc.description.departmentBiology
dc.relation.doihttps://doi.org/10.1016/j.heliyon.2021.e08281
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeTemple University. College of Science and Technology
dc.creator.orcidMusumeci|0000-0002-8260-8890
dc.temple.creatorMusumeci, Giuseppe
refterms.dateFOA2022-04-29T19:21:44Z


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