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dc.creatorZaback, Martin
dc.creatorTiwari, Ekta
dc.creatorKrupka, Alexander J.
dc.creatorMarchionne, Francesca
dc.creatorNegro, Francesco
dc.creatorLemay, Michel
dc.creatorThompson, Christopher K.
dc.identifier.citationZaback M, Tiwari E, Krupka AJ, Marchionne F, Negro F, Lemay MA and Thompson CK (2022) Toward Assessing the Functional Connectivity of Spinal Neurons. Front. Neural Circuits 16:839521. doi: 10.3389/fncir.2022.839521
dc.description.abstractSpinal interneurons play a critical role in motor output. A given interneuron may receive convergent input from several different sensory modalities and descending centers and relay this information to just as many targets. Therefore, there is a critical need to quantify populations of spinal interneurons simultaneously. Here, we quantify the functional connectivity of spinal neurons through the concurrent recording of populations of lumbar interneurons and hindlimb motor units in the in vivo cat model during activation of either the ipsilateral sural nerve or contralateral tibial nerve. Two microelectrode arrays were placed into lamina VII, one at L3 and a second at L6/7, while an electrode array was placed on the surface of the exposed muscle. Stimulation of tibial and sural nerves elicited similar changes in the discharge rate of both interneurons and motor units. However, these same neurons showed highly significant differences in prevalence and magnitude of correlated activity underlying these two forms of afferent drive. Activation of the ipsilateral sural nerve resulted in highly correlated activity, particularly at the caudal array. In contrast, the contralateral tibial nerve resulted in less, but more widespread correlated activity at both arrays. These data suggest that the ipsilateral sural nerve has dense projections onto caudal lumbar spinal neurons, while contralateral tibial nerve has a sparse pattern of projections.
dc.format.extent15 pages
dc.relation.ispartofOpen Access Publishing Fund
dc.relation.haspartFrontiers in Neural Circuits, Vol. 16
dc.relation.isreferencedbyFrontiers Media
dc.rightsAttribution CC BY
dc.subjectHigh density arrays
dc.subjectSingle units
dc.subjectSpinal cord circuitry
dc.titleToward assessing the functional connectivity of spinal neurons
dc.type.genreJournal article
dc.description.departmentHealth and Rehabilitation Sciences
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact
dc.description.schoolcollegeTemple University. College of Public Health
dc.description.schoolcollegeTemple University. College of Engineering
dc.description.sponsorTemple University Libraries Open Access Publishing Fund, 2021-2022 (Philadelphia, Pa.)
dc.temple.creatorZaback, Martin
dc.temple.creatorTiwari, Ekta
dc.temple.creatorKrupka, Alexander J.
dc.temple.creatorMarchionne, Francesca
dc.temple.creatorLemay, Michel A.
dc.temple.creatorThompson, Christopher K.

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