Distinct alterations in cerebellar connectivity with substantia nigra and ventral tegmental area in Parkinson’s disease
Genre
Journal articleDate
2022-02-28Department
PsychologyNeuroscience
Subject
Basal gangliaCerebellum
Diseases of the nervous system
Motor control
Neuroscience
Parkinson's disease
Permanent link to this record
http://hdl.handle.net/20.500.12613/7457
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https://doi.org/10.1038/s41598-022-07020-xAbstract
In Parkinson’s disease (PD), neurodegeneration of dopaminergic neurons occurs in the midbrain, specifically targeting the substantia nigra (SN), while leaving the ventral tegmental area (VTA) relatively spared in early phases of the disease. Although the SN and VTA are known to be functionally dissociable in healthy adults, it remains unclear how this dissociation is altered in PD. To examine this issue, we performed a whole-brain analysis to compare functional connectivity in PD to healthy adults using resting-state functional magnetic resonance imaging (rs-fMRI) data compiled from three independent datasets. Our analysis showed that across the sample, the SN had greater connectivity with the precuneus, anterior cingulate gyrus, and areas of the occipital cortex, partially replicating our previous work in healthy young adults. Notably, we also found that, in PD, VTA-right cerebellum connectivity was higher than SN-right cerebellum connectivity, whereas the opposite trend occurred in healthy controls. This double dissociation may reflect a compensatory role of the cerebellum in PD and could provide a potential target for future study and treatment.Citation
O’Shea, I.M., Popal, H.S., Olson, I.R. et al. Distinct alterations in cerebellar connectivity with substantia nigra and ventral tegmental area in Parkinson’s disease. Sci Rep 12, 3289 (2022). https://doi.org/10.1038/s41598-022-07020-xCitation to related work
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http://dx.doi.org/10.34944/dspace/7435