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dc.creatorBlutfield, Matthew S.
dc.creatorLohre, Jenna M.
dc.creatorPawich, Derek A.
dc.creatorVlahovic, Tracey
dc.date.accessioned2022-01-26T17:35:19Z
dc.date.available2022-01-26T17:35:19Z
dc.date.issued2015-07-17
dc.identifier.citationBlutfield MS, Lohre JM, Pawich DA, Vlahovic TC. The Immunologic Response to Trichophyton Rubrum in Lower Extremity Fungal Infections. Journal of Fungi. 2015;1(2):130-137. doi:10.3390/jof1020130
dc.identifier.issn2309-608X
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/7266
dc.identifier.urihttp://hdl.handle.net/20.500.12613/7287
dc.description.abstractManifestations of Trichophyton rubrum infestations, such as tinea pedis, tinea cruris, and tinea corporis, are among the most common human skin diseases seen throughout the world. About 80% of patients presenting with acute dermatophytosis respond well to topical antifungal treatment. However, the remaining 20% of patients progress into a chronic state of dermatophytosis, which is resistant to antifungal treatment. Therefore, it is necessary to have a better understanding and appreciation for the diverse immune responses to Trichophyton as this is critical for the development of therapeutic strategies for those individuals who suffer from a chronic manifestation of Trichophyton rubrum (T. rubrum) infection. As a result, a comprehensive literature review was conducted to review and discuss previous studies that evaluated the human body’s defense to T. rubrum infections and to understand why and how these fungal infections invade the host defense system. Our research revealed that a cell-mediated immune response is critical in defending the body against T. rubrum. However, this organism has mechanisms that enable it to evade the immune system. Therefore, a more successful treatment for chronic T. rubrum infection would involve targeting the mechanisms of T. rubrum that diminish the immune response, while restoring the cell-mediated immune response.
dc.format.extent8 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofFaculty/ Researcher Works
dc.relation.haspartJournal of Fungi, Vol. 1, No. 2
dc.relation.isreferencedbyMDPI
dc.rightsAttribution CC BY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectTrichophyton rubrum
dc.subjectDermatophytosis
dc.subjectCell-mediated immune response
dc.subjectToll-like receptor
dc.subjectKeratinocyte
dc.subjectMacrophage
dc.subjectDendritic cell
dc.subjectFungal infection
dc.subjectTinea pedis
dc.titleThe Immunologic Response to Trichophyton Rubrum in Lower Extremity Fungal Infections
dc.typeText
dc.type.genreJournal article
dc.description.departmentPodiatric Medicine
dc.relation.doihttps://doi.org/10.3390/jof1020130
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeTemple University. School of Podiatric Medicine
dc.creator.orcidVlahovic|0000-0002-5310-4706
dc.temple.creatorBlutfield, Matthew S.
dc.temple.creatorLohre, Jenna M.
dc.temple.creatorPawich, Derek A.
dc.temple.creatorVlahovic, Tracey C.
refterms.dateFOA2022-01-26T17:35:19Z


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