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    Candida albicans Immunotherapy for Verrucae Plantaris

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    Vlahovic-JournalArticle-2015.pdf
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    Genre
    Journal article
    Date
    2015-09-01
    Author
    Vlahovic, Tracey cc
    Spadone, Samuel
    Dunn, S. Patrick
    Fussell, Tara
    Hersh, Ian
    Green, Tyson
    Merrill, Jeff
    Ghosh, Payel
    Tran, Tran
    Department
    Podiatric Medicine
    Permanent link to this record
    http://hdl.handle.net/20.500.12613/7285
    
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    DOI
    https://doi.org/10.7547/14-062
    Abstract
    Background: Verrucae plantaris is a viral disease caused by human papilloma virus that is commonly seen in the office setting and is often challenging to treat owing to its high recurrence rate and recalcitrant profile. Candida albicans intralesional injections have been hypothesized to incite an immunogenic response toward the virus. Methods: We report on the immunotherapeutic effect of intralesional injection of C albicans into plantar verrucae with a retrospective medical record analysis of 80 patients. Using a luer-lock syringe, 0.1 to 0.3 mL of C albicans antigen was injected into either the first known lesion or the largest lesion. Results: The success rate of intralesional C albicans, defined as total clearance of the lesion, was 65%, which may be underestimated because patients lost to follow-up were included in the 35% failure rate. It was also found that female patients with a previous tissue-destructive treatment process were more than four times more likely to respond to C albicans therapy, whereas this effect was less pronounced in the male patient population. Conclusions: These results indicate that a series of intralesional injections of C albicans is an effective and efficient method of treatment for verrucae plantaris.
    Citation
    Vlahovic TC, Spadone S, Dunn SP, et al. Candida albicans Immunotherapy for Verrucae Plantaris. J Am Podiatr Med Assoc. 2015;105(5):395-400. doi:10.7547/14-062
    Citation to related work
    American Podiatric Medical Association
    Has part
    Journal of the American Podiatric Medical Association, Vol. 105, No. 5
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    ae974a485f413a2113503eed53cd6c53
    http://dx.doi.org/10.34944/dspace/7264
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