• Trauma and PTSD: Understanding the Brain in the Midst of Recovery

      Blessley, Emily; Do, Alyssa; Forry, Taylor; Moonthianngam, Pathompon; Heidelbaugh, Samantha; May, Dana (Temple University. Grey Matters, 2021-05)
      Post-traumatic stress disorder (PTSD) should be considered in anyone exposed to a traumatic event [1]. Approximately 60% of men and 50% of women will experience trauma at some point in their life. Nonetheless, trauma exposure does not guarantee the onset of PTSD symptoms; typically, only 4% of men and 10% of women end up developing PTSD after experiencing trauma [2]. The psychological mechanisms in which PTSD is prevented within an individual is not well understood. Thus, recognition of the onset of symptoms and comprehension of the neurobiology of this disorder are critical for diagnosis, treatment and recovery [1].
    • Expounding on Anorexia: Cognitive and Structural Outcomes

      Brown, Remya; Kunta, Charita; Abraham, Ashish; Kuchibhatla, Vishwanka; Carroll, Ethan; Tassoni, Molly (Temple University. Grey Matters, 2021-05)
    • The Feasibility of Diagnosing Psychiatric Disorders with Neuroimaging

      Ghias, Kubarah; Vitelli, Gianna; Peters, Melissa; Abbasi, Aleena; Sposit, Chelsea; Matton, Matthew (Temple University. Grey Matters, 2021-05)
      In the past few years, the number of individuals seeking treatment for psychiatric disorders has increased significantly [1]. Mental illness statistics continue to rise year after year. In his 2010 book, Robert Whitaker reported that the number of mentally ill had tripled in the past two decades [2]. In 2019, 56.4% of individuals ages 18-25 received mental health treatment, compared to the 45.9% receiving treatment in 2008 [3]. Suicide is now the second leading cause of death in persons aged 18-34. As of December 2020, Hedegaard and colleagues reported that suicide rates have increased by 35% since 1999. Furthermore, the report stated that 90% of the people who died by suicide were confirmed to have shown symptoms of mental illness [4]. These statistics are concerning and bring about a number of questions, one being the effectiveness of prescription drugs. Just how effective are these treatments? Furthermore, what limits improvement within the fields of psychiatry and psychology? One surprising limitation may be the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). The DSM-5 classifies mental disorders using set symptom-based criteria and is the standard for clinical diagnoses. However, this manual does not come without fault and controversy. A growing number of researchers have cited concern about false positives that occur as a result of the Diagnostic Manual’s recently lowered diagnostic thresholds [5]. Neuroimaging, also known as brain scans, may be useful for improving diagnostic accuracy. Neuroimaging approaches involve assessing structural anatomy and functional activity. If health professionals can diagnose individuals based on brain abnormalities associated with psychiatric disorders, then there may be a lower chance of misdiagnosis and error. This article will explore neuroimaging literature to assess the feasibility of this approach. It will be organized by first considering current issues within the field of psychiatry and a review of neuroimaging methods before a discussion of potential strengths and limitations of the approach.
    • Grey Matters, Issue 1, Spring 2021

      Shah, Mansi (Temple University. Grey Matters, 2021-05)
    • A Whole New World - Exploring Emotion in Music

      Brodsky, Rachel; Buddhiraju, Kirvani; Szmacinski, Ola; Calaku, Katie; Hobson, Sam; Brucato, Maria (Temple University. Grey Matters, 2021-05)
      When Disney movies open with a murmur of classi cal music, crescendoing into powerful waves, they immediately transport us to animated lands of princes and princesses, talking animals and evil stepmothers. Or if you haven’t watched a Disney movie in a while, what about the recent allure of the sea shanty? When listening to the now-famil iar rhythm of the folk songs that traditionally accompanied labo rious tasks while at sea, we imagine ourselves on a 19th century ship, helping to raise the sail or hoist up the anchor. How do we create entire worlds for ourselves, whether familiar or from cen turies before, based on the music we hear? Human perception of music is influenced by pitch, key, tempo and other factors, which evoke emotion by activating the limbic and paralimbic systems [1, 2]. That said, the whole story behind music is still being sounded out, and some current theories are explored below.
    • Bridging the Gap Between the Science & People Affected by Traumatic Brain Injury

      Sotelo, Angelica; Baffoe-Bonnie, Jude; Shah, Aarohi; Michel, Erin; Jozwik, Matthew; Cában Rivera, Carolina (Temple University. Grey Matters, 2021-05)
      Most Americans have probably seen media coverage of a National Football League (NFL) game. Because American football is a full contact sport, it is probably not surprising that frequent collisions between players result in concussions, or “mild” traumatic brain injury (TBI) [1]. While concussions have been associated with American football and its players since 1994, athletes are not the only people affected by them [2]. 69 million individuals sustain TBI each year worldwide [3]. According to the Centers for Disease Control and Prevention (CDC), while a concussion itself is not life-threatening, it is the after effects of the concussion that contribute to complications which may hinder a person’s quality of life for some time [1]. Recent research on the oculomotor system and neuro-optometric rehabilitation may offer affected individuals more opportunities for concussion recovery. Concussions affect our brain in a multitude of ways, including our physical, chemical, mental, and visual processes; however, neuro-optometric rehabilitation is a glimmer of hope for those recovering from traumatic brain injury.
    • Fungus Among Us

      Hilty, Christopher; Kitabwalla, Fatema; Pandey, Abhi; Bhatti, Saira; Sigler, Danni; Farkas, Daniel (Temple University. Grey Matters, 2021-05)
      Everyone knows that drugs are bad for you. That’s why they’re illegal, right? This outdated idea is facing increased scrutiny, as we’ve already begun to see the prohibition and regulation of some of these substances being reexamined. For example, marijuana is federally recognized as a Schedule 1 drug, a classification that implies it has a high abuse potential and no recognized medicinal value. However, this classification has been challenged by many recent studies that have shown its potential as a treatment option for various conditions ranging from mild nausea to debilitating epilepsy [1]. Another drug in this Schedule 1 category is psilocybin, which was once considered a revolutionary tool in psychotherapy. This drug isn’t some modern creation synthesized in a lab, it’s a naturally occurring substance found in certain species of mushrooms . The ritual consumption of these mushrooms dates back thousands of years in Mexico, where it had been used for both medicinal and spiritual purposes [2]. In the late 1950’s, isolation of the psy choactive psilocybin molecule allowed scientists to evaluate its potential as a treatment option for various mood disorders and alcoholism [3]. However, as the war on drugs ramped up, funding for these studies dried out. After a hiatus that spanned multiple decades, research on this promising molecule is finally resuming. Recent studies indicate that psilocybin can be a powerful treat ment option for various ailments such as obsessive compulsive disorder (OCD), addiction, and depression. Its ability to produce a “mystical-type experience” is thought to be correlated with its effectiveness, though the cause of this experience is still under investigation [4]. Despite the uncertainty surrounding this phenomenon, the positive therapeutic results of the drug offer hope for a new tool to fight the rising mental health issues and addic tion epidemics that lurk below the surface of our society.
    • Brain-Machine Interface

      Lua, Esmeralda; McGuigan, Daniel; Rahaman, Arafat; Wanders, Siena; Neguch, Natalya; Bullock, Trent (Temple University. Grey Matters, 2021-05)
      Requiring collaboration in the fields of neurobiology, electrophysiology, engineering, computer science, and biomedicine, Brain-Machine Interfaces (BMIs) are an emerging multidisciplinary technology with countless potential benefits. The ability to record and interpret neuronal activity at a higher resolution and specificity is one of the exciting promises of BMIs. The applications of this technology provide hope for a vast number of individuals who suffer from a wide range of neurological diseases and disorders. It can also be applied to artificial prostheses, to provide limb sensation for amputees. Although BMIs hold immense potential, questions within the realm of neuroethics have raised concern. In particular, the possible exploitation that could arise through medical practices with the advancement of technology [1]. Where humans may potentially be given capabilities that surpass the norm, changing the perception of what it means to be human [1]. It is important to take into account that there are BMIs currently in place that have provided relief for various conditions. To name a few, the use of deep brain stimulation in patients with Parkinson’s, spinal cord stimulation for those with intractable pain, and the use of motor prosthesis for patients with epilepsy [1]. However, these methods oftentimes only provide temporary or mild relief and are not inerrant. The trajectory of the BMIs outlined herein aims toward finding an ideal invasive mechanism to solve these drawbacks of mild and temporary relief. There are a vast number of neurological disorders that continue to trouble humanity both emotionally and economically [1], that could substantially change through the use of BMIs.
    • The Undeniable Link Between the Brain and Gut

      Rhoads, Brigham; Jurewicz, Abigail; Nghe, Amy; Oliveras, Kiana; Nelson, Vanessa; Gingerich, Alexa (Temple University. Grey Matters, 2021-05)
      Nausea, heartburn, indigestion, constipation, and stomach pain are all kinds of gastrointestinal problems we have faced before. They are easy to dismiss as merely an upset stomach, but this mentality could build up and ultimately be detrimental to mental and physical health. Improperly caring for the digestive system can lead to extensive intestinal health issues. The microbiome is a collection of all of the microorganisms that thrive in the human digestive system. It is a cohesive network of beneficial, neutral, and negative bacteria, fungi, protozoa, and viruses that help digest foods that are otherwise indigestible by our digestive tract among many other functions. Neglecting intestinal health by not nourishing the microbiome with proper nutrients, abusing medications, or excessive alcohol consumption can lead to a host of different health problems. For example, sleep disturbances, like insomnia, are a common symptom of a struggling gut. They can lead to chronic fatigue because the majority of serotonin, the neurotransmitter that is pivotal in mood and sleep, is manufactured in the gut [1]. A more acute health crisis that can develop from improper care of one’s gut is the formation of peptic ulcers in the stomach or small intestine. Peptic ulcers are caused by a breakdown of the mucus membrane in the digestive tract and result in chest and abdominal pain, weight loss, trouble breathing, and in extreme cases expulsion of blood [2]. Who would have thought that what we eat could affect the development of healthy gut flora, which then can contribute to declining mental and physical health? This article investigates topics regarding the gut’s impact on body and mind, what lifestyle choices cause dysbiosis, and how Parkinson’s Disease can develop beginning in the gut to demonstrate how central the gut is to overall wellness.
    • The Joker’s Therapy Sessions

      Al-Tikriti, Meena; Wolf, Madison; Sajeev, Nikita; Baak, Stephen; Myers, Hailey; Salla, Nikki (Temple University. Grey Matters, 2021-05)
    • ALS: Diagnosis by Deduction

      Morgan, Gideon; Vajipayajula, Dhruv; Shah, Aarohi; McGrath, Rose; Swanchara, Melissa; Leonard, Brian; Leonard|0000-0002-4901-0977 (Temple University. Grey Matters, 2021-05)
    • The Social and Emotional Toll of Narcolepsy

      Mehta, Rutvik; Jiwanji, Mariyah; Singhal, Rashi; Gillam, Emily; Lockwood, Kathryn; Quarmley, Megan; Quarmley|0000-0003-2115-2196 (Temple University. Grey Matters, 2021-05)
      Normally, turning on the light in your house is as easy as flipping a switch. Now, imagine if the light didn’t work properly. Imagine that flipping a switch on or off meant guessing if the light would turn on or off, or just flicker. Not knowing what your light is going to do at any moment would severely limit your ability to function in your house and would be exhausting, frustrating, and very disrupting. For people with narcolepsy, this is an everyday reality. The light represents the brain of a person with narcolepsy, as they can feel tired or awake at any time, not knowing when sleep will attack. Although the physiological effects of narcolepsy are well-known and studied more, the social and emotional toll is not talked about as much but can have equally devastating and life-altering effects.
    • Walking Again

      Rahman, Areebah; Paroya, Sonya; Abraham, Ashish; Ayala, Victoria; Clay, Barbara; Young, Jennica; Young|0000-0003-2594-9418 (Temple University. Grey Matters, 2021-05)
      Spinal cord injuries are known to be debilitating and in many cases, limit the ability to walk. This article will investigate how a research group in Germany has enabled functional recovery in mice after spinal cord injury. Motor vehicle accidents are one of the leading causes of traumatic spinal cord injuries (SCIs), along with catastrophic falls and sports injuries. Traumatic SCIs result from forced impact, such as from a car accident or sports injury, whereas non-traumatic SCIs involve an infection or slow degeneration of bones [1].
    • 1971: The Bloodied Legacy of the United States in South Asia

      Khanna, Yesh (2021-05)
      In 1971, South Asia saw one of the most horrific genocides in modern history. It took place in East Pakistan (now known as Bangladesh) under the oversight of General Yahya Khan. This genocidal campaign was named Operation Searchlight; its primary objective was to 'suppress' the members and sympathizers of the Awami League - the Bengali nationalist political party, led by Sheikh Mujib-ur-Rahman - protesting for greater autonomy of East Pakistan. Later, they started demanding complete secession and the creation of 'Bangladesh'. The military crackdown began on March 25th in Dhaka and neighboring areas with the Pakistani army killing civilians, firing indiscriminately at unarmed university students, and raping women. Even though the U.S. consulate in Dhaka witnessed these horrors and reported each and every update to Washington, the Nixon administration not only chose to turn a blind eye to the atrocities being committed by the Pakistani army in East Pakistan but secretly approved of Yahya's crackdown.
    • Friction in China-Japan Relations: Causes and Challenges

      Khanna, Yesh (2021-09)
      Because of its location, Japan has an array of unique neighbors, though not all of them hold a warm attitude toward the country. China is one such example - the recent actions of the Chinese government pertaining to the Senkaku Islands, its growing military might, and the country's hegemonic aspirations are all reasons why the Japanese Ministry of Defense classifies China as the biggest current threat to Japan. Given the facts that Japan is one of the United States' most strategic allies and China is the biggest threat to the United States' superpower status, it becomes more important than ever to better understand the history and the future of relations between the two countries. This piece explores various causes of Japan-China tensions and the strategic challenges that China poses to Japan.
    • The Use of Eyewitness Testimony as Evidence in Criminal Cases

      Shah, Pushti (Temple University. Grey Matters, 2021-12)
      Eyewitness testimony in court is shown to highly sway the opinion of jurors. Jurors trust a confident eyewitness and believe they are telling the truth and that their testimony is accurate [1]. Therefore, it is important that the individuals allowed to testify are accurate in their recollections. The enhanced ability to extract and examine DNA and the widespread usage of DNA as evidence in recent years has exonerated innocent individuals convicted of crimes that occurred before forensic DNA evidence was well understood. Out of those exonerated by DNA evidence, 75% were sentenced based on faulty eyewitness testimony [2]. Stress conditions significantly impact how memories are stored and how well they can later be recalled [3]. Therefore, the investigator questioning style must take stress levels and type of event witnessed into consideration. This has the potential to inform eye witness interviewing techniques and thereby improve the reliability of testimony, ultimately reducing the number of wrongful convictions.
    • The Laughing Brain: The Neuroscience Behind Comedy

      Sposit, Chelsea (Temple University. Grey Matters, 2021-12)
      Imagine yourself sitting in front of your television watching Saturday Night Live (SNL). Michael Che just blurted a line on the Weekend Update segment “the CDC [is] warning people not to eat raw cookie dough because it may contain germs that cause diarrhea, but on the bright side, you can eat cookie dough without gaining weight!” [1]. Not much thought goes into your laughter– as it is an innate physical reaction that comes as naturally as crying [2]. But, have you ever wondered why that line evoked such a reaction from you, but not from your mom who was also watching the show alongside you? In the neuroscientific community, there is a dearth of knowledge on the science behind comedy [3]. Following that intrigue, this article will investigate the neuroscience behind laughter and comedy by utilizing existing research to foster a strong understanding of this topic and potential areas to be investigated in the future.
    • Trapped Within

      Armstrong, Bridget (Temple University. Grey Matters, 2021-12)
      Imagine you hear someone talking to your loved ones, “I’m sorry…. their chance of survival is small”. What is this? What's going on? ‘Maybe this is a dream’, you start to think to yourself as you try to wake yourself up. You are unsuccessful in waking up, and you still see complete darkness. You start to hear a doctor talk to your family about ending life support. You are conscious, afraid, your heart is racing, and to make matters worse, you realize you cannot move or speak. “How can I tell them that I am still here and alive?” you say to yourself in your head. This is merely a glimpse of what locked-in syndrome may feel like. If you have ever experienced or heard of sleep paralysis, where you are conscious, but unable to move your body, except your eyes, then you can begin to appreciate what individuals living with locked-in syndrome experience continuously. Instead of your experience lasting for a few minutes, like sleep paralysis, locked-in syndrome could be something you are trapped in for the rest of your life. This article examines the world of locked-in syndrome, its etiologies, types of locked-in syndrome, and what diagnosis/treatment looks like.
    • Alice in Wonderland Syndrome: Down the Rabbit Hole

      Ataher, Aleena (Temple University. Grey Matters, 2021-12)
      A young girl, age seven, wakes up one more morning to find her limbs have grown dramatically overnight. Her arm, once a mere ten inches, now extends fifteen feet from her body, while her hands have shrunk to a size similar to that of a blueberry. Her leg, once a comfortable few feet from her body, has narrowed to just centimeters in width. Amid her confusion, she recalls a situation similar to her own in a story she once read about a girl who follows a rabbit down a hole: Lewis Caroll’s popular children’s novel, Alice’s Adventures in Wonderland. British psychiatrist Dr. John Todd noticed this same resemblance during the 1950s when six of his adolescent patients came to him complaining of migraines and epileptic episodes, simultaneously reporting symptoms parallel to Alice’s experiences.
    • Running on Empty: How COVID Has Affected Our Social Skills

      Kohol, Jaya (Temple University. Grey Matters, 2021-12)
      Being away from others can impact our state of mind. The lack of social interaction may invite feelings of isolation and loneliness. But, what does it look like on a biopsychosocial level when one experiences prolonged isolation? Scientists have taken a deep dive into discovering what this does to our minds. With lockdown restrictions being enforced across the world, incidences of psychosocial problems, which affect the individual and their social group, have increased.Isolation due to COVID-19 has had several negative effects on the population, but has especially put a strain on our social skills. This article will explore how COVID has impacted the way we communicate and will communicate with others.