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dc.creatorMorrione, Andrea
dc.creatorValentinis, Barbara
dc.creatorResnicoff, Mariana
dc.creatorXu, Shi-Qiong
dc.creatorBaserga, Renato
dc.date.accessioned2021-11-09T15:40:40Z
dc.date.available2021-11-09T15:40:40Z
dc.date.issued1997-10-17
dc.identifier.citationAndrea Morrione, Barbara Valentinis, Mariana Resnicoff, Shi-qiong Xu, Renato Baserga, The Role of mGrb10α in Insulin-like Growth Factor I-mediated Growth, Journal of Biological Chemistry, Volume 272, Issue 42, 1997, Pages 26382-26387, ISSN 0021-9258, https://doi.org/10.1074/jbc.272.42.26382.
dc.identifier.issn1083-351X
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/7089
dc.identifier.urihttp://hdl.handle.net/20.500.12613/7109
dc.description.abstractSeveral isoforms of Grb10 are known to interact with either the insulin receptor or the insulin-like growth factor I (IGF-I) receptor, or both. Inasmuch as the data in the literature on the function of Grb10 are not always concordant, we have investigated the role of one of these isoforms, mGrb10α, in cell proliferation. For this purpose, a plasmid expressing mGrb10α was stably transfected into p6 cells and other mouse embryo fibroblast cell lines. An overexpressed mGrb10α inhibits IGF-I-mediated growth, causes a delay in the S and G2 phases of the cell cycle, and partially reverses the transformed phenotype. In contrast, it has no effect on insulin stimulation of cell proliferation. These studies indicate that this isoform of Grb10 has an inhibitory effect on IGF-I signaling of cell proliferation.
dc.format.extent6 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofFaculty/ Researcher Works
dc.relation.haspartJournal of Biological Chemistry, Vol. 272, No. 42
dc.relation.isreferencedbyElsevier
dc.rightsAttribution CC BY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleThe Role of mGrb10α in Insulin-like Growth Factor I-mediated Growth
dc.typeText
dc.type.genreJournal article
dc.description.departmentBiology
dc.relation.doihttps://doi.org/10.1074/jbc.272.42.26382
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeTemple University. College of Science and Technology
dc.creator.orcidMorrione|0000-0002-2319-7884
dc.temple.creatorMorrione, Andrea
refterms.dateFOA2021-11-09T15:40:40Z


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