The Role of mGrb10α in Insulin-like Growth Factor I-mediated Growth
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AbstractSeveral isoforms of Grb10 are known to interact with either the insulin receptor or the insulin-like growth factor I (IGF-I) receptor, or both. Inasmuch as the data in the literature on the function of Grb10 are not always concordant, we have investigated the role of one of these isoforms, mGrb10α, in cell proliferation. For this purpose, a plasmid expressing mGrb10α was stably transfected into p6 cells and other mouse embryo fibroblast cell lines. An overexpressed mGrb10α inhibits IGF-I-mediated growth, causes a delay in the S and G2 phases of the cell cycle, and partially reverses the transformed phenotype. In contrast, it has no effect on insulin stimulation of cell proliferation. These studies indicate that this isoform of Grb10 has an inhibitory effect on IGF-I signaling of cell proliferation.
CitationAndrea Morrione, Barbara Valentinis, Mariana Resnicoff, Shi-qiong Xu, Renato Baserga, The Role of mGrb10α in Insulin-like Growth Factor I-mediated Growth, Journal of Biological Chemistry, Volume 272, Issue 42, 1997, Pages 26382-26387, ISSN 0021-9258, https://doi.org/10.1074/jbc.272.42.26382.
Citation to related workElsevier
Has partJournal of Biological Chemistry, Vol. 272, No. 42
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