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dc.creatorPeruzzi, Francesca
dc.creatorPrisco, Marco
dc.creatorMorrione, Andrea
dc.creatorValentinis, Barbara
dc.creatorBaserga, Renato
dc.date.accessioned2021-11-09T15:40:39Z
dc.date.available2021-11-09T15:40:39Z
dc.date.issued2001-07-13
dc.identifier.citationFrancesca Peruzzi, Marco Prisco, Andrea Morrione, Barbara Valentinis, Renato Baserga, Anti-apoptotic Signaling of the Insulin-like Growth Factor-I Receptor through Mitochondrial Translocation of c-Raf and Nedd4, Journal of Biological Chemistry, Volume 276, Issue 28, 2001, Pages 25990-25996, ISSN 0021-9258, https://doi.org/10.1074/jbc.M103188200.
dc.identifier.issn1083-351X
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/7085
dc.identifier.urihttp://hdl.handle.net/20.500.12613/7105
dc.description.abstractThe type 1 insulin-like growth factor receptor (IGF-IR) sends a strong anti-apoptotic signal by at least three different pathways. By using mutants of the IGF-IR, we showed that one of the pathways depends on residues of the IGF-IR (serines 1280–1283) that interact with 14.3.3 proteins. The result is the activation of Raf-1 and the mitochondrial translocation of both Raf-1 and Nedd4, a target of caspases. A mutant IGF-IR in which the serines at positions 1280–1283 have been mutated to alanine does not protect from apoptosis and fails to translocate Nedd4 or Raf-1 to the mitochondria. This failure is accompanied by a loss of cytochrome c from the mitochondria. The 14.3.3/Raf-1/Nedd4 pathway is operative in the presence or absence of the insulin receptor substrate-1.
dc.format.extent7 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofFaculty/ Researcher Works
dc.relation.haspartJournal of Biological Chemistry, Vol. 276, No. 28
dc.relation.isreferencedbyElsevier
dc.rightsAttribution CC BY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleAnti-apoptotic Signaling of the Insulin-like Growth Factor-I Receptor through Mitochondrial Translocation of c-Raf and Nedd4
dc.typeText
dc.type.genreJournal article
dc.description.departmentBiology
dc.relation.doihttps://doi.org/10.1074/jbc.M103188200
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeTemple University. College of Science and Technology
dc.creator.orcidMorrione|0000-0002-2319-7884
dc.temple.creatorMorrione, Andrea
refterms.dateFOA2021-11-09T15:40:39Z


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