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    Dichotomy of decorin activity on the insulin-like growth factor-I system

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    Morrione-Postprint-2013-01-25.pdf
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    Genre
    Post-print
    Date
    2013-01-25
    Author
    Morrione, Andrea cc
    Neill, Thomas
    Iozzo, Renato V.
    Department
    Biology
    Subject
    Bladder cancer
    Cancer growth
    Decorin
    Insulin-like growth factor receptor I
    Signaling
    Permanent link to this record
    http://hdl.handle.net/20.500.12613/7095
    
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    DOI
    https://doi.org/10.1111/febs.12149
    Abstract
    The stromal-specific proteoglycan decorin has emerged in recent years as a critical regulator of tumor initiation and progression. Decorin regulates the biology of various types of cancer by modulating the activity of several receptor tyrosine kinases coordinating growth, survival, migration, and angiogenesis. Decorin binds to surface receptors for epidermal growth factor and hepatocyte growth factor with high affinity, and negatively regulates their activity and signaling via robust internalization and eventual degradation. The insulin-like growth factor (IGF)-I system plays a critical role in the regulation of cell growth both in vivo and in vitro. The IGF-I receptor (IGF-IR) is also essential for cellular transformation, owing to its ability to enhance cell proliferation and protect cancer cells from apoptosis. Recent data have pointed to a role of decorin in regulating the IGF-I system in both nontransformed and transformed cells. Significantly, there is a surprising dichotomy in the mechanism of decorin action on IGF-IR signaling, which differs considerably between physiological and pathological cellular models. In this review, we summarize the current knowledge on decorin regulation of the IGF-I system in normal and transformed cells, and discuss possible decorin-based therapeutic approaches to target IGF-IR-driven tumors.
    Citation
    Morrione, A., Neill, T. and Iozzo, R.V. (2013), Dichotomy of decorin activity on the insulin-like growth factor-I system. FEBS J, 280: 2138-2149. https://doi.org/10.1111/febs.12149
    Citation to related work
    Wiley
    This is the peer reviewed version of the following article: Morrione, A., Neill, T. and Iozzo, R.V. (2013), Dichotomy of decorin activity on the insulin-like growth factor-I system. FEBS J, 280: 2138-2149. https://doi.org/10.1111/febs.12149
    Has part
    FEBS Journal, Vol. 280, No. 10
    ADA compliance
    For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
    ae974a485f413a2113503eed53cd6c53
    http://dx.doi.org/10.34944/dspace/7075
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