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dc.creatorTanimoto, Ryuta
dc.creatorLu, Kuojung G.
dc.creatorXu, Shi-Qiong
dc.creatorBuraschi, Simone
dc.creatorBelfiore, Antonino
dc.creatorIozzzo, Renato V.
dc.creatorMorrione, Andrea
dc.date.accessioned2021-11-09T15:40:32Z
dc.date.available2021-11-09T15:40:32Z
dc.date.issued2016-07-27
dc.identifier.citationTanimoto R, Lu KG, Xu S-Q, Buraschi S, Belfiore A, Iozzo RV and Morrione A (2016) Mechanisms of Progranulin Action and Regulation in Genitourinary Cancers. Front. Endocrinol. 7:100. doi: 10.3389/fendo.2016.00100
dc.identifier.issn1664-2392
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/7064
dc.identifier.urihttp://hdl.handle.net/20.500.12613/7084
dc.description.abstractThe growth factor progranulin has emerged in recent years as a critical regulator of transformation in several cancer models, including breast cancer, glioblastomas, leukemias, and hepatocellular carcinomas. Several laboratories, including ours, have also demonstrated an important role of progranulin in several genitourinary cancers, including ovarian, endometrial, cervical, prostate, and bladder tumors, where progranulin acts as an autocrine growth factor thereby modulating motility and invasion of transformed cells. In this review, we will focus on the mechanisms of action and regulation of progranulin signaling in genitourinary cancers with a special emphasis on prostate and bladder tumors.
dc.format.extent7 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofFaculty/ Researcher Works
dc.relation.haspartFrontiers in Endocrinology, Vol. 7, No. 100
dc.relation.isreferencedbyFrontiers Media
dc.rightsAttribution CC BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectProgranulin
dc.subjectBladder and prostate cancer
dc.subjectMotility
dc.subjectAnchorage-independent growth
dc.subjectTumor formation in vivo
dc.titleMechanisms of Progranulin Action and Regulation in Genitourinary Cancers
dc.typeText
dc.type.genreJournal article
dc.description.departmentBiology
dc.relation.doihttps://doi.org/10.3389/fendo.2016.00100
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeTemple University. College of Science and Technology
dc.creator.orcidMorrione|0000-0002-2319-7884
dc.temple.creatorMorrione, Andrea
refterms.dateFOA2021-11-09T15:40:32Z


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