Mechanisms of Progranulin Action and Regulation in Genitourinary Cancers
Lu, Kuojung G.
Iozzzo, Renato V.
Bladder and prostate cancer
Tumor formation in vivo
Permanent link to this recordhttp://hdl.handle.net/20.500.12613/7084
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AbstractThe growth factor progranulin has emerged in recent years as a critical regulator of transformation in several cancer models, including breast cancer, glioblastomas, leukemias, and hepatocellular carcinomas. Several laboratories, including ours, have also demonstrated an important role of progranulin in several genitourinary cancers, including ovarian, endometrial, cervical, prostate, and bladder tumors, where progranulin acts as an autocrine growth factor thereby modulating motility and invasion of transformed cells. In this review, we will focus on the mechanisms of action and regulation of progranulin signaling in genitourinary cancers with a special emphasis on prostate and bladder tumors.
CitationTanimoto R, Lu KG, Xu S-Q, Buraschi S, Belfiore A, Iozzo RV and Morrione A (2016) Mechanisms of Progranulin Action and Regulation in Genitourinary Cancers. Front. Endocrinol. 7:100. doi: 10.3389/fendo.2016.00100
Citation to related workFrontiers Media
Has partFrontiers in Endocrinology, Vol. 7, No. 100
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