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dc.creatorBuraschi, Simone
dc.creatorXi, Shi-Qiong
dc.creatorStefanello, Manuela
dc.creatorMoskalev, Igor
dc.creatorMorcavallo, Alaide
dc.creatorGenua, Marco
dc.creatorTanimoto, Ryuta
dc.creatorBirbe, Ruth
dc.creatorPeiper, Stephen C.
dc.creatorGomella, Leonard G.
dc.creatorBelfiore, Antonino
dc.creatorBlack, Peter C.
dc.creatorIozzo, Renato V.
dc.creatorMorrione, Andrea
dc.date.accessioned2021-11-09T15:40:32Z
dc.date.available2021-11-09T15:40:32Z
dc.date.issued2016-05-23
dc.identifier.citationBuraschi S., Xu S., Stefanello M., Moskalev I., Morcavallo A., Genua M., Tanimoto R., Birbe R., Peiper S. C., Gomella L. G., Belfiore A., Black P. C., Iozzo R. V., et al Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin. Oncotarget. 2016; 7: 39980-39995. Retrieved from https://www.oncotarget.com/article/9556/text/
dc.identifier.issn1949-2553
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/7063
dc.identifier.urihttp://hdl.handle.net/20.500.12613/7083
dc.description.abstractWe have recently demonstrated a critical role for progranulin in bladder cancer. Progranulin contributes, as an autocrine growth factor, to the transformed phenotype by modulating Akt-and MAPK-driven motility, invasion and anchorage-independent growth. Progranulin also induces F-actin remodeling by interacting with the F-actin binding protein drebrin. In addition, progranulin is overexpressed in invasive bladder cancer compared to normal tissue controls, suggesting that progranulin might play a key role in driving the transition to the invasive phenotype of urothelial cancer. However, it is not established whether targeting progranulin could have therapeutic effects on bladder cancer. In this study, we stably depleted urothelial cancer cells of endogenous progranulin by shRNA approaches and determined that progranulin depletion severely inhibited the ability of tumorigenic urothelial cancer cells to migrate, invade and grow in anchorage-independency. We further demonstrate that progranulin expression is critical for tumor growth in vivo, in both xenograft and orthotopic tumor models. Notably, progranulin levels correlated with response to cisplatin treatment and were upregulated in bladder tumors. Our data indicate that progranulin may constitute a novel target for therapeutic intervention in bladder tumors. In addition, progranulin may serve as a novel biomarker for bladder cancer.
dc.format.extent16 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofFaculty/ Researcher Works
dc.relation.haspartOncotarget, Vol. 7, No. 26
dc.relation.isreferencedbyImpact Journals
dc.rightsAttribution CC BY
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.subjectProgranulin
dc.subjectBladder cancer
dc.subjectMotility
dc.subjectAnchorage-independent growth
dc.subjectTumor formation in vivo
dc.titleSuppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin
dc.typeText
dc.type.genreJournal article
dc.description.departmentBiology
dc.relation.doihttps://doi.org/10.18632/oncotarget.9556
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeTemple University. College of Science and Technology
dc.creator.orcidMorrione|0000-0002-2319-7884
dc.temple.creatorMorrione, Andrea
refterms.dateFOA2021-11-09T15:40:32Z


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