Genre
Journal articleDate
2021-02-12Department
BiologySubject
IGF systemCancer
Transcriptional regulators
Functional regulation
Circular RNAs
IGF2BPs
ADAR
DDR1
E-cadherin
Decorin
Permanent link to this record
http://hdl.handle.net/20.500.12613/7073
Metadata
Show full item recordDOI
https://doi.org/10.3390/biom11020273Abstract
The insulin-like growth factor (IGF) system is a dynamic network of proteins, which includes cognate ligands, membrane receptors, ligand binding proteins and functional downstream effectors. It plays a critical role in regulating several important physiological processes including cell growth, metabolism and differentiation. Importantly, alterations in expression levels or activation of components of the IGF network are implicated in many pathological conditions including diabetes, obesity and cancer initiation and progression. In this review we will initially cover some general aspects of IGF action and regulation in cancer and then focus in particular on the role of transcriptional regulators and novel interacting proteins, which functionally contribute in fine tuning IGF1R signaling in several cancer models. A deeper understanding of the biological relevance of this network of IGF1R modulators might provide novel therapeutic opportunities to block this system in neoplasia.Citation
Mancarella, C.; Morrione, A.; Scotlandi, K. Novel Regulators of the IGF System in Cancer. Biomolecules 2021, 11, 273. https://doi.org/10.3390/biom11020273Citation to related work
MDPIHas part
Biomolecules, Vol. 11ADA compliance
For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.eduae974a485f413a2113503eed53cd6c53
http://dx.doi.org/10.34944/dspace/7053