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dc.creatorNi, Dong
dc.creatorTang, TingTing
dc.creatorLu, Yifan
dc.creatorXu, Keman
dc.creatorShao, Ying
dc.creatorSaaoud, Fatma
dc.creatorSaredy, Jason
dc.creatorLiu, Lu
dc.creatorDrummer IV, Charles
dc.creatorSun, Yu
dc.creatorHu, Wenhui
dc.creatorLopez-Pastrana, Jahaira
dc.creatorLuo, Jin J.
dc.creatorJiang, Xiaohua
dc.creatorChoi, Eric T.
dc.creatorWang, Hong
dc.creatorYang, Xiaofeng
dc.identifier.citationNi D, Tang T, Lu Y, Xu K, Shao Y, Saaoud F, Saredy J, Liu L, Drummer C IV, Sun Y, Hu W, Lopez-Pastrana J, Luo JJ, Jiang X, Choi ET, Wang H and Yang X (2021) Canonical Secretomes, Innate Immune Caspase-1-, 4/11-Gasdermin D Non-Canonical Secretomes and Exosomes May Contribute to Maintain Treg-Ness for Treg Immunosuppression, Tissue Repair and Modulate Anti-Tumor Immunity via ROS Pathways. Front. Immunol. 12:678201. doi: 10.3389/fimmu.2021.678201
dc.description.abstractWe performed a transcriptomic analyses using the strategies we pioneered and made the following findings: 1) Normal lymphoid Tregs, diseased kidney Tregs, splenic Tregs from mice with injured muscle have 3, 17 and 3 specific (S-) pathways, respectively; 2) Tumor splenic Tregs share 12 pathways with tumor Tregs; tumor splenic Tregs and tumor Tregs have 11 and 8 S-pathways, respectively; 3) Normal and non-tumor disease Tregs upregulate some of novel 2641 canonical secretomic genes (SGs) with 24 pathways, and tumor Tregs upregulate canonical secretomes with 17 pathways; 4) Normal and non-tumor disease tissue Tregs upregulate some of novel 6560 exosome SGs with 56 exosome SG pathways (ESP), tumor Treg ESP are more focused than other Tregs; 5) Normal, non-tumor diseased Treg and tumor Tregs upregulate some of novel 961 innate immune caspase-1 SGs and 1223 innate immune caspase-4 SGs to fulfill their tissue/SG-specific and shared functions; 6) Most tissue Treg transcriptomes are controlled by Foxp3; and Tumor Tregs had increased Foxp3 non-collaboration genes with ROS and 17 other pathways; 7) Immune checkpoint receptor PD-1 does, but CTLA-4 does not, play significant roles in promoting Treg upregulated genes in normal and non-tumor disease tissue Tregs; and tumor splenic and tumor Tregs have certain CTLA-4-, and PD-1-, non-collaboration transcriptomic changes with innate immune dominant pathways; 8) Tumor Tregs downregulate more immunometabolic and innate immune memory (trained immunity) genes than Tregs from other groups; and 11) ROS significantly regulate Treg transcriptomes; and ROS-suppressed genes are downregulated more in tumor Tregs than Tregs from other groups. Our results have provided novel insights on the roles of Tregs in normal, injuries, regeneration, tumor conditions and some of canonical and innate immune non-canonical secretomes via ROS-regulatory mechanisms and new therapeutic targets for immunosuppression, tissue repair, cardiovascular diseases, chronic kidney disease, autoimmune diseases, transplantation, and cancers.
dc.format.extent38 pages
dc.relation.ispartofCOVID-19 Research
dc.relation.haspartFrontiers in Immunology, Vol. 12
dc.relation.isreferencedbyFrontiers Media
dc.rightsAttribution CC BY
dc.subjectCD4+Foxp3+ regulatory T cells (Treg)
dc.subjectCanonical secretome
dc.subjectInnate immune caspase-1 dependent secretome
dc.subjectInnate immune caspase-4/11 dependent secretome
dc.subjectImmune checkpoint receptors
dc.titleCanonical Secretomes, Innate Immune Caspase-1-, 4/11-Gasdermin D Non-Canonical Secretomes and Exosomes May Contribute to Maintain Treg-Ness for Treg Immunosuppression, Tissue Repair and Modulate Anti-Tumor Immunity via ROS Pathways
dc.type.genreJournal article
dc.contributor.groupCenters for Cardiovascular Research (Temple University)
dc.contributor.groupMetabolic Disease Research & Thrombosis Research (Temple University)
dc.contributor.groupInflammation, Translational & Clinical Lung Research (Temple University)
dc.description.departmentCardiovascular Sciences
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact
dc.description.schoolcollegeLewis Katz School of Medicine
dc.temple.creatorNi, Dong
dc.temple.creatorTang, TingTing
dc.temple.creatorLu, Yifan
dc.temple.creatorXu, Keman
dc.temple.creatorShao, Ying
dc.temple.creatorSaaoud, Fatma
dc.temple.creatorSaredy, Jason
dc.temple.creatorLiu, Lu
dc.temple.creatorDrummer IV, Charles
dc.temple.creatorSun, Yu
dc.temple.creatorHu, Wenhui
dc.temple.creatorLopez-Pastrana, Jahaira
dc.temple.creatorLuo, Jin J.
dc.temple.creatorJiang, Xiaohua
dc.temple.creatorChoi, Eric T.
dc.temple.creatorWang, Hong
dc.temple.creatorYang, Xiaofeng

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