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dc.creatorBernstein, David
dc.creatorJiang, Xinpei
dc.creatorRom, Slava
dc.date.accessioned2021-10-25T13:42:46Z
dc.date.available2021-10-25T13:42:46Z
dc.date.issued2021-05-26
dc.identifier.citationBernstein, D.L.; Jiang, X.; Rom, S. let-7 microRNAs: Their Role in Cerebral and Cardiovascular Diseases, Inflammation, Cancer, and Their Regulation. Biomedicines 2021, 9, 606. https://doi.org/10.3390/biomedicines9060606
dc.identifier.issn2227-9059
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/6993
dc.identifier.urihttp://hdl.handle.net/20.500.12613/7012
dc.description.abstractThe let-7 family is among the first microRNAs found. Recent investigations have indicated that it is highly expressed in many systems, including cerebral and cardiovascular systems. Numerous studies have implicated the aberrant expression of let-7 members in cardiovascular diseases, such as stroke, myocardial infarction (MI), cardiac fibrosis, and atherosclerosis as well as in the inflammation related to these diseases. Furthermore, the let-7 microRNAs are involved in development and differentiation of embryonic stem cells in the cardiovascular system. Numerous genes have been identified as target genes of let-7, as well as a number of the let-7’ regulators. Further studies are necessary to identify the gene targets and signaling pathways of let-7 in cardiovascular diseases and inflammatory processes. The bulk of the let-7’ regulatory proteins are well studied in development, proliferation, differentiation, and cancer, but their roles in inflammation, cardiovascular diseases, and/or stroke are not well understood. Further knowledge on the regulation of let-7 is crucial for therapeutic advances. This review focuses on research progress regarding the roles of let-7 and their regulation in cerebral and cardiovascular diseases and associated inflammation.
dc.format.extent18 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofCOVID-19 Research
dc.relation.haspartBiomedicines, Vol. 9, No. 6
dc.relation.isreferencedbyMDPI
dc.rightsAttribution CC BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMicroRNAs
dc.subjectLet-7
dc.subjectStroke
dc.subjectCardiovascular
dc.subjectInflammation
dc.titlelet-7 microRNAs: Their Role in Cerebral and Cardiovascular Diseases, Inflammation, Cancer, and Their Regulation
dc.typeText
dc.type.genreJournal article
dc.contributor.groupCenter for Substance Abuse Research (Temple University)
dc.description.departmentPathology and Laboratory Medicine
dc.relation.doihttps://doi.org/10.3390/biomedicines9060606
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeLewis Katz School of Medicine
dc.creator.orcidBernstein|0000-0003-3340-205X
dc.creator.orcidRom|0000-0002-1050-1955
dc.temple.creatorBernstein, David L.
dc.temple.creatorJiang, Xinpei
dc.temple.creatorRom, Slava
refterms.dateFOA2021-10-25T13:42:46Z


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