Correlation of vaccine-elicited antibody levels and neutralizing activities against SARS-CoV-2 and its variants
Khan, Adil I.
Saribas, A. Sami
Padhiar, Nigam H.
Luo, Jin Jun
GroupCenter for Metabolic Disease Research (Temple University)
DepartmentPathology and Laboratory Medicine
Permanent link to this recordhttp://hdl.handle.net/20.500.12613/7010
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AbstractBoth Pfizer-BNT162b2 and Moderna-mRNA-1273 vaccines can elicit an effective immune response against SARS-CoV-2 infection. However, the elicited serum antibody levels vary substantially and longitudinally decrease after vaccination. We examined the correlation of vaccination-induced IgG levels and neutralization titers against newly emerged variants remains and demonstrate a significant reduction of neutralization activities against the variants (B.1.1.7, B.1.525, and B.1.351) in Pfizer or Moderna vaccined sera. There was a significant and positive correlation between serum IgG levels and ID50 titers for not only SARS-CoV-2 WT but also the variants. These findings indicate that a high level of anti-spike IgG may offer better protection against infection from SARS-CoV-2 and its variants. Therefore, it is necessary to longitudinally monitor specific serum IgG level for evaluating the protective efficacy of the vaccines against SARS-CoV-2 and its new variants.
CitationJinbiao Liu, Brittany H Bodnar, Xu Wang, Peng Wang, Fengzhen Meng, Adil I Khan, A Sami Saribas, Nigam H Padhiar, Elizabeth McCluskey, Sahil Shah, Jin Jun Luo, Wen-Hui Hu, Wen-Zhe Ho. Correlation of vaccine-elicited antibody levels and neutralizing activities against SARS-CoV-2 and its variants. bioRxiv 2021.05.31.445871; doi: https://doi.org/10.1101/2021.05.31.445871
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