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dc.creatorMaugeri, Grazia
dc.creatorD'Agata, Velia
dc.creatorMagri, Benedetta
dc.creatorRoggio, Federico
dc.creatorCastorina, Alessandro
dc.creatorRavalli, Silvia
dc.creatorDi Rosa, Michelino
dc.creatorMusumeci, Giuseppe
dc.date.accessioned2021-10-25T13:42:44Z
dc.date.available2021-10-25T13:42:44Z
dc.date.issued2021-06-18
dc.identifier.citationMaugeri, G.; D’Agata, V.; Magrì, B.; Roggio, F.; Castorina, A.; Ravalli, S.; Di Rosa, M.; Musumeci, G. Neuroprotective Effects of Physical Activity via the Adaptation of Astrocytes. Cells 2021, 10, 1542. https://doi.org/10.3390/cells10061542
dc.identifier.issn2073-4409
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/6987
dc.identifier.urihttp://hdl.handle.net/20.500.12613/7006
dc.description.abstractThe multifold benefits of regular physical exercise have been largely demonstrated in human and animal models. Several studies have reported the beneficial effects of physical activity, both in peripheral tissues and in the central nervous system (CNS). Regular exercise improves cognition, brain plasticity, neurogenesis and reduces the symptoms of neurodegenerative diseases, making timeless the principle of “mens sana in corpore sano” (i.e., a healthy mind in a healthy body). Physical exercise promotes morphological and functional changes in the brain, acting not only in neurons but also in astrocytes, which represent the most numerous glial cells in the brain. The multiple effects of exercise on astrocytes comprise the increased number of new astrocytes, the maintenance of basal levels of catecholamine, the increase in glutamate uptake, the major release of trophic factors and better astrocytic coverage of cerebral blood vessels. The purpose of this review is to highlight the effects of exercise on brain function, emphasize the role of astrocytes in the healthy CNS, and provide an update for a better understanding of the effects of physical exercise in the modulation of astrocyte function.
dc.format.extent13 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofCOVID-19 Research
dc.relation.haspartCells, Vol. 10, No. 6
dc.relation.isreferencedbyMDPI
dc.rightsAttribution CC BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectExercise
dc.subjectAstrocytes
dc.subjectNeuron
dc.subjectBrain functions
dc.titleNeuroprotective Effects of Physical Activity via the Adaptation of Astrocytes
dc.typeText
dc.type.genreJournal article
dc.description.departmentBiology
dc.relation.doihttps://doi.org/10.3390/cells10061542
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeTemple University. College of Science and Technology
dc.creator.orcidMusumeci|0000-0002-8260-8890
dc.temple.creatorMusumeci, Giuseppe
refterms.dateFOA2021-10-25T13:42:44Z


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