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dc.creatorDi Domenico, Marina
dc.creatorDe Rosa, Alfredo
dc.creatorDi Gaudio, Francesca
dc.creatorInternicola, Pietro
dc.creatorBettini, Cinzia
dc.creatorSalzano, Nicola
dc.creatorCastrianni, Davide
dc.creatorMarotta, Andrea
dc.creatorBoccellino, Mariarosaria
dc.date.accessioned2021-10-25T13:42:44Z
dc.date.available2021-10-25T13:42:44Z
dc.date.issued2021-06-10
dc.identifier.citationDi Domenico, M.; De Rosa, A.; Di Gaudio, F.; Internicola, P.; Bettini, C.; Salzano, N.; Castrianni, D.; Marotta, A.; Boccellino, M. Diagnostic Accuracy of a New Antigen Test for SARS-CoV-2 Detection. Int. J. Environ. Res. Public Health 2021, 18, 6310. https://doi.org/10.3390/ijerph18126310
dc.identifier.issn1660-4601
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/6986
dc.identifier.urihttp://hdl.handle.net/20.500.12613/7005
dc.description.abstractBackground and aims: Quick and reliable diagnostic tools play an important role in controlling the spread of the SARS-Cov-2 pandemic. The aim of this study was to evaluate the diagnostic accuracy of a new cyto-salivary antigen test aimed at detecting the presence of antigens for SARS-CoV-2, as compared by the gold standard RT-PCR and a lateral flow test. Methods: A total of 433 healthy volunteers were enrolled in the study and the sensitivity and specificity of the new cyto-salivary antigen test were calculated, as compared to the RT-PCR nasopharyngeal swab and to the lateral flow test. Results: A total of 433 samples were collected and tested at the Mediterranean Fair in Palermo from February 2021 until April 2021. The new cyto-salivary antigen had a sensitivity of 100% and a specificity of 94.2%. The sensitivity and the specificity of the lateral flow test were 55% and 100%, respectively. Conclusions: The new cyto-salivary antigen test detected more positive cases than the RT-PCR in a sample of asymptomatic subjects, demonstrating to be a promising tool for a more sensitive diagnosis of COVID-19. Further studies are warranted to better characterize its diagnostic accuracy.
dc.format.extent9 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofCOVID-19 Research
dc.relation.haspartInternational Journal of Environmental Research and Public Health, Vol. 18, No. 12
dc.relation.isreferencedbyMDPI
dc.rightsAttribution CC BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectRespiratory disease COVID-19
dc.subjectSARS-CoV-2
dc.subjectELISA
dc.subjectCyto-salivary test
dc.subjectRT-PCR
dc.subjectLateral flow test
dc.titleDiagnostic Accuracy of a New Antigen Test for SARS-CoV-2 Detection
dc.typeText
dc.type.genreJournal article
dc.description.departmentBiology
dc.relation.doihttps://doi.org/10.3390/ijerph18126310
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeTemple University. College of Science and Technology
dc.creator.orcidDi Domenico|0000-0002-6201-4200
dc.temple.creatorDi Domenico, Marina
refterms.dateFOA2021-10-25T13:42:44Z


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