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dc.creatorNakrani, Rima
dc.creatorYeung, Ho-Man
dc.creatorArnon, Matan
dc.creatorSelby, Alexandra
dc.creatorBurgert-Lon, Christine
dc.creatorKamat, Bhishak
dc.date.accessioned2021-10-18T15:52:11Z
dc.date.available2021-10-18T15:52:11Z
dc.date.issued2021-09-20
dc.identifier.citationRima Nakrani, Ho-Man Yeung, Matan Arnon, Alexandra Selby, Christine Burgert-Lon & Bhishak Kamat (2021) An unusual presentation of non-IBD related colorectal primary extranodal diffuse large B cell lymphoma with a colo-colonic fistula, Journal of Community Hospital Internal Medicine Perspectives, 11:5, 662-666, DOI: 10.1080/20009666.2021.1951946
dc.identifier.issn2000-9666
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/6946
dc.identifier.urihttp://hdl.handle.net/20.500.12613/6965
dc.description.abstractDiffuse large B cell lymphoma of the sigmoid colon and rectum is relatively uncommon and aggressive. Due to its nonspecific symptomatology, patients are often diagnosed late into the disease and present with life-threatening complications, such as hemorrhage, obstruction, or perforation, requiring emergent surgical intervention. Patients with colorectal lymphoma typically have inflammatory bowel disease or immunosuppression. We present a case of a 79-year-old male with no known inflammatory bowel disease or immunosuppression, who had significant weight loss, diarrhea, and abdominal fullness, found by CT to have irregular wall thickening of the recto-sigmoid colon along with a colo-colonic fistula, concerning for bowel perforation. Endoscopic evaluation and biopsy confirmed the diagnosis of recto-sigmoid Diffuse large B cell lymphoma, with a PET/CT scan revealing stage IV disease. He had a partial response to six cycles of palliative reduced dose R-CHOP and is currently receiving palliative radiation to the sigmoid colon and rectum. Surgery and/or chemoradiation remain the mainstay therapy for this condition. Clinicians, however, must consider patient's functional, nutritional, and clinical status prior to choosing an optimal therapeutic regimen. This case illustrates a unique clinical presentation of this condition and the associated diagnostic and therapeutic challenges that arise in order to prevent life-threatening complications.
dc.format.extent6 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofOpen Access Publishing Fund
dc.relation.haspartJournal of Community Hospital Internal Medicine Perspectives, Vol. 11, Iss. 5
dc.relation.isreferencedbyTaylor & Francis Open Access
dc.rightsAttribution-NonCommercial CC BY-NC
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectColorectal lymphoma
dc.subjectColonic fistula
dc.subjectDiffuse large B-cell lymphoma
dc.subjectColon cancer
dc.subjectColorectal cancer
dc.titleAn unusual presentation of non-IBD related colorectal primary extranodal diffuse large B cell lymphoma with a colo-colonic fistula
dc.typeText
dc.type.genreJournal article
dc.contributor.groupTemple University. Hospital
dc.description.departmentMedicine
dc.description.departmentPathology
dc.description.departmentRadiology
dc.relation.doihttps://doi.org/10.1080/20009666.2021.1951946
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeLewis Katz School of Medicine
dc.description.sponsorTemple University Libraries Open Access Publishing Fund, 2021-2022 (Philadelphia, Pa.)
dc.creator.orcidNakrani|0000-0001-7820-9048
dc.creator.orcidYeung|0000-0002-7188-9738
dc.temple.creatorNakrania, Rima
dc.temple.creatorYeung, Ho-Man
dc.temple.creatorArnon, Matan
dc.temple.creatorSelby, Alexandra
dc.temple.creatorBurgert-Lon, Christine
dc.temple.creatorKamat, Bhishak
refterms.dateFOA2021-10-18T15:52:11Z


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