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dc.creatorChroni, Antonia
dc.creatorMiura, Sayaka
dc.creatorOladeinde, Olumide
dc.creatorAly, Vivian
dc.creatorKumar, Sudhir
dc.date.accessioned2021-10-05T19:38:51Z
dc.date.available2021-10-05T19:38:51Z
dc.date.issued2021-08-25
dc.identifier.citationChroni, A., Miura, S., Oladeinde, O. et al. Migrations of cancer cells through the lens of phylogenetic biogeography. Sci Rep 11, 17184 (2021). https://doi-org/10.1038/s41598-021-96215-9
dc.identifier.issn2045-2322
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/6940
dc.identifier.urihttp://hdl.handle.net/20.500.12613/6959
dc.description.abstractMalignant cells leave their initial tumor of growth and disperse to other tissues to form metastases. Dispersals also occur in nature when individuals in a population migrate from their area of origin to colonize other habitats. In cancer, phylogenetic biogeography is concerned with the source and trajectory of cell movements. We examine the suitability of primary features of organismal biogeography, including genetic diversification, dispersal, extinction, vicariance, and founder effects, to describe and reconstruct clone migration events among tumors. We used computer-simulated data to compare fits of seven biogeographic models and evaluate models’ performance in clone migration reconstruction. Models considering founder effects and dispersals were often better fit for the clone phylogenetic patterns, especially for polyclonal seeding and reseeding of metastases. However, simpler biogeographic models produced more accurate estimates of cell migration histories. Analyses of empirical datasets of basal-like breast cancer had model fits consistent with the patterns seen in the analysis of computer-simulated datasets. Our analyses reveal the powers and pitfalls of biogeographic models for modeling and inferring clone migration histories using tumor genome variation data. We conclude that the principles of molecular evolution and organismal biogeography are useful in these endeavors but that the available models and methods need to be applied judiciously.
dc.format.extent13 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofFaculty/ Researcher Works
dc.relation.haspartScientific Reports, Iss. 11
dc.relation.isreferencedbyNature Research
dc.rightsAttribution CC BY
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBiogeography
dc.subjectCancer
dc.subjectEvolution
dc.titleMigrations of cancer cells through the lens of phylogenetic biogeography
dc.typeText
dc.type.genreJournal article
dc.contributor.groupInstitute for Genomics and Evolutionary Medicine (Temple University)
dc.description.departmentBiology
dc.relation.doihttp://doi.org/10.1038/s41598-021-96215-9
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeTemple University. College of Science and Technology
dc.temple.creatorChroni, Antonia
dc.temple.creatorMiura, Sayaka
dc.temple.creatorOladeinde, Olumide
dc.temple.creatorAly, Vivian
dc.temple.creatorKumar, Sudhir
refterms.dateFOA2021-10-05T19:38:51Z


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