Show simple item record

dc.creatorMascavage, Linda M.
dc.creatorWilson, M. L.
dc.creatorDalton, David R.
dc.date.accessioned2021-04-16T14:35:09Z
dc.date.available2021-04-16T14:35:09Z
dc.date.issued2006
dc.identifier.citationL. M. Mascavage, M. L. Wilson and D. R. Dalton, “Syntheses of Morphine and Codeine (1992 - 2002): Templates for Exploration of Synthetic Tools”, Current Organic Synthesis (2006) 3: 99. https://doi.org/10.2174/157017906775473939
dc.identifier.issn1570-1794
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/6290
dc.identifier.urihttp://hdl.handle.net/20.500.12613/6308
dc.description.abstractMorphine (1) and its O-methylated analogue codeine (2), analgesic alkaloids of the opium poppy (Papaver Somniferium), have been targets of organic chemists engaged in synthetic activities for at least half a century. The "first" (Gates) and "most efficient" (Rice) syntheses of morphine (1) and codeine (2) are well known and have been reviewed and analyzed extensively numerous times. However, syntheses of the same two alkaloids that have been reported since 1992 and which have been used as devices to advance the art of organic synthesis are not as widely recognized and they have not been as thoroughly reviewed. Here they are analyzed in the spirit of the use of these two compounds as templates. Further, since both racemic and enantiospecific syntheses are important and since all eight (8) approaches (since 1992) are sufficiently different so as to warrant more tha n superficial examination, they are all considered.
dc.format.extent22 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofFaculty/ Researcher Works
dc.relation.haspartCurrent Organic Synthesis, Vol. 3, Iss. 1
dc.relation.isreferencedbyBentham Science Publishers
dc.rightsAttribution CC BY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectTetrahydrofuran (THF)
dc.subjectCrystal x-ray diffraction
dc.subjectThebainone
dc.subjectOsmium tetroxide dihydroxylation
dc.subjectLipase oxidation
dc.subjectDEAD
dc.subjectCodeine
dc.titleSyntheses of Morphine and Codeine (1992 - 2002): Templates for Exploration of Synthetic Tools
dc.typeText
dc.type.genreJournal article
dc.description.departmentChemistry
dc.relation.doihttps://doi.org/10.2174/157017906775473939
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeTemple University. College of Science and Technology
dc.temple.creatorDalton, David R.
refterms.dateFOA2021-04-16T14:35:09Z


Files in this item

Thumbnail
Name:
Dalton-JournalArticle-2006.pdf
Size:
637.3Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record

Attribution CC BY
Except where otherwise noted, this item's license is described as Attribution CC BY