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dc.contributor.advisorDanowsky, Joseph
dc.creatorKraynak, Jack
dc.date.accessioned2021-04-06T13:46:47Z
dc.date.available2021-04-06T13:46:47Z
dc.date.issued2021
dc.identifier.urihttp://hdl.handle.net/20.500.12613/6299
dc.descriptionThis research project was completed as part of the Honors Technical Communication by Design course.
dc.description.abstractThis proposal seeks to minimize cell death while extrusion bioprinting with a gelatin-alginate bioink. Extrusion bioprinting was chosen over other types of bioprinting due to its accessibility and cost to researchers. Two different nozzles, cylindrical and conical, are examined to determine a mechanical aspect of extrusion bioprinting that can be modified to greatly minimize the cell death of bioprinted scaffolds. Gelatin-algiate bioinks can vary in concentration, and this concentration was also varied as a candidate solution to obtain the optimal concentration while maintaining a high cell survivability. The conical nozzle was chosen as the optimal printing nozzle with low shear stress, low cell damage, and highest cell viability. The 4% gelatin 5% alginate bioink was chosen as the optimal bioink concentration with optimal viscosity and high cell viability. Together, the use of this nozzle and this concentration bioink will greatly minimize the cell damage that occurs during extrusion bioprinting, boosting the quality of extrusion printing, and making it all-around more viable. Extrusion bioprinting, due to its improved cell death percentage, will be utilized more often by researchers – this will potentially accelerate the innovation of bioprinting as an overall technology towards the final goal of bioprinting a fully functioning organ.
dc.format.extent42 pages
dc.languageEnglish
dc.language.isoeng
dc.publisherTemple University. Libraries
dc.relation.ispartofLivingstone Undergraduate Research Awards
dc.relation.isreferencedbyLivingstone Undergraduate Research Awards website: https://sites.temple.edu/livingstone/2021-livingstone-undergraduate-research-award-in-stem/
dc.rightsIN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available.
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectBioprint
dc.subjectBioprinting
dc.subjectBioink
dc.subjectBioprinted scaffold
dc.subjectCell death
dc.subjectCell death bioprinting
dc.subjectExtrusion bioprinting
dc.subjectGelatin-alginate bioink
dc.subjectHydrogel bioprinting
dc.titleMinimizing Cell Death During the Extrusion Bioprinting of Gelatin-Alginate Bioinks
dc.typeText
dc.type.genreResearch project
dc.description.departmentBioengineering
dc.relation.doihttp://dx.doi.org/10.34944/dspace/6281
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.awardLivingstone Undergraduate Research Award in STEM Disciplines
dc.description.schoolcollegeTemple University. College of Engineering
dc.temple.creatorKraynak, Jack
refterms.dateFOA2021-04-06T13:46:47Z


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