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dc.creatorGerkin, Richard C.
dc.creatorOhla, Kathrin
dc.creatorVeldhuizen, Maria G.
dc.creatorJoseph, Paule V.
dc.creatorKelly, Christine E.
dc.creatorBakke, Alyssa J.
dc.creatorSteele, Kimberley E.
dc.creatorFarruggia, Michael C.
dc.creatorPellegrino, Robert
dc.creatorPepino, Marta Y.
dc.creatorBouysset, Cédric
dc.creatorSoler, Graciela M.
dc.creatorPereda-Loth, Veronica
dc.creatorDibattista, Michele
dc.creatorCooper, Keiland W.
dc.creatorCroijmans, Ilja
dc.creatorDi Pizio, Antonella
dc.creatorOzdener, Mehmet Hakan
dc.creatorFjaeldstad, Alexander W.
dc.creatorLin, Cailu
dc.creatorSandell, Mari A.
dc.creatorSingh, Preet B.
dc.creatorBrindha, V. Evelyn
dc.creatorOlsson, Shannon B.
dc.creatorSaraiva, Luis R.
dc.creatorAhuja, Gaurav
dc.creatorAlwashahi, Mohammed K.
dc.creatorBhutani, Surabhi
dc.creatorD'Errico, Anna
dc.creatorFornazieri, Marco A.
dc.creatorGolebiowski, Jérôme
dc.creatorHwang, Liang Dar
dc.creatorÖztürk, Lina
dc.creatorRoura, Eugeni
dc.creatorSpinelli, Sara
dc.creatorWhitcroft, Katherine L.
dc.creatorFaraji, Farhoud
dc.creatorFischmeister, Florian Ph S.
dc.creatorHeinbockel, Thomas
dc.creatorHsieh, Julien W.
dc.creatorHuart, Caroline
dc.creatorKonstantinidis, Iordanis
dc.creatorMenini, Anna
dc.creatorMorini, Gabriella
dc.creatorOlofsson, Jonas K.
dc.creatorPhilpott, Carl M.
dc.creatorPierron, Denis
dc.creatorShields, Vonnie D.C.
dc.creatorVoznessenskaya, Vera V.
dc.creatorAlbayay, Javier
dc.creatorAltundag, Aytug
dc.creatorBensafi, Moustafa
dc.creatorBock, María Adelaida
dc.creatorCalcinoni, Orietta
dc.creatorFredborg, William
dc.creatorLaudamiel, Christophe
dc.creatorLim, Juyun
dc.creatorLundström, Johan N.
dc.creatorMacchi, Alberto
dc.creatorMeyer, Pablo
dc.creatorMoein, Shima T.
dc.creatorSantamaría, Enrique
dc.creatorSengupta, Debarka
dc.creatorDominguez, Paloma Rohlfs
dc.creatorYanik, Hüseyin
dc.creatorHummel, Thomas
dc.creatorHayes, John E.
dc.creatorReed, Danielle R.
dc.creatorNiv, Masha Y.
dc.creatorMunger, Steven D.
dc.creatorParma, Valentina
dc.date.accessioned2021-03-29T18:20:50Z
dc.date.available2021-03-29T18:20:50Z
dc.date.issued2020-12-25
dc.identifier.citationGerkin, R.C., Ohla, K., Veldhuizen, M.G., et. al. Recent Smell Loss Is the Best Predictor of COVID-19 Among Individuals With Recent Respiratory Symptoms, Chemical Senses, Volume 46, 2021, bjaa081, https://doi.org/10.1093/chemse/bjaa081
dc.identifier.issn0379-864X
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/6247
dc.identifier.urihttp://hdl.handle.net/20.500.12613/6265
dc.description.abstractIn a preregistered, cross-sectional study, we investigated whether olfactory loss is a reliable predictor of COVID-19 using a crowdsourced questionnaire in 23 languages to assess symptoms in individuals self-reporting recent respiratory illness. We quantified changes in chemosensory abilities during the course of the respiratory illness using 0–100 visual analog scales (VAS) for participants reporting a positive (C19+; n = 4148) or negative (C19−; n = 546) COVID-19 laboratory test outcome. Logistic regression models identified univariate and multivariate predictors of COVID-19 status and post-COVID-19 olfactory recovery. Both C19+ and C19− groups exhibited smell loss, but it was significantly larger in C19+ participants (mean ± SD, C19+: −82.5 ± 27.2 points; C19−: −59.8 ± 37.7). Smell loss during illness was the best predictor of COVID-19 in both univariate and multivariate models (ROC AUC = 0.72). Additional variables provide negligible model improvement. VAS ratings of smell loss were more predictive than binary chemosensory yes/no-questions or other cardinal symptoms (e.g., fever). Olfactory recovery within 40 days of respiratory symptom onset was reported for ~50% of participants and was best predicted by time since respiratory symptom onset. We find that quantified smell loss is the best predictor of COVID-19 amongst those with symptoms of respiratory illness. To aid clinicians and contact tracers in identifying individuals with a high likelihood of having COVID-19, we propose a novel 0–10 scale to screen for recent olfactory loss, the ODoR-19. We find that numeric ratings ≤2 indicate high odds of symptomatic COVID-19 (4 < OR < 10). Once independently validated, this tool could be deployed when viral lab tests are impractical or unavailable.
dc.format.extent12 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofCOVID-19 Research
dc.relation.haspartChemical Senses, Vol. 46
dc.relation.isreferencedbyOxford University Press (OUP)
dc.rightsAll Rights Reserved
dc.subjectAnosmia
dc.subjectChemosensory
dc.subjectCoronavirus
dc.subjectHyposmia
dc.subjectOlfactory
dc.subjectPrediction
dc.titleRecent Smell Loss Is the Best Predictor of COVID-19 Among Individuals With Recent Respiratory Symptoms
dc.typeText
dc.type.genreJournal article
dc.description.departmentPsychology
dc.relation.doihttps://doi.org/10.1093/chemse/bjaa081
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeTemple University. College of Liberal Arts
dc.temple.creatorParma, Valentina
refterms.dateFOA2021-03-29T18:20:50Z


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