From examining the relationship between (corona)viral adhesins and galectins to glyco-perspectives
AuthorKlein, Michael L.
GroupInstitute of Computational Molecular Science (Temple University)
Permanent link to this recordhttp://hdl.handle.net/20.500.12613/6262
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AbstractGlycan-lectin recognition is vital to processes that impact human health, including viral infections. Proceeding from crystallographical evidence of case studies on adeno-, corona-, and rotaviral spike proteins, the relationship of these adhesins to mammalian galectins was examined by computational similarity assessments. Intrafamily diversity among human galectins was in the range of that to these viral surface proteins. Our findings are offered to inspire the consideration of lectin-based approaches to thwart infection by present and future viral threats, also mentioning possible implications for vaccine development.
CitationKlein, M.L., Romero, A., Kaltner, H., Percec, V., Gabius, H.-J. From examining the relationship between (corona)viral adhesins and galectins to glyco-perspectives. Biophys. J. 120(6), 1031-1039 (2021). https://doi.org/10.1016/j.bpj.2020.11.020
Citation to related workElsevier
Has partBiophysical Journal, Vol. 120, Iss. 6
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