Cellular mechanisms underlying neurological/neuropsychiatric manifestations of COVID‐19
Genre
Post-printDate
2020-12-10Group
Center for Metabolic Disease Research (Temple University)Department
Pathology and Laboratory MedicineNeurology and Pharmacology
Subject
Brain organoidsCOVID‐19
iPS cells
Neural cells
Neuroinvasion
Neurology
Neuropsychiatry
Neurovirulence
SARS‐CoV‐2
Permanent link to this record
http://hdl.handle.net/20.500.12613/6260
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https://doi.org/10.1002/jmv.26720Abstract
Patients with severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection manifest mainly respiratory symptoms. However, clinical observations frequently identified neurological symptoms and neuropsychiatric disorders related to COVID‐19 (Neuro‐SARS2). Accumulated robust evidence indicates that Neuro‐SARS2 may play an important role in aggravating the disease severity and mortality. Understanding the neuropathogenesis and cellular mechanisms underlying Neuro‐SARS2 is crucial for both basic research and clinical practice to establish effective strategies for early detection/diagnosis, prevention, and treatment. In this review, we comprehensively examine current evidence of SARS‐CoV‐2 infection in various neural cells including neurons, microglia/macrophages, astrocytes, pericytes/endothelial cells, ependymocytes/choroid epithelial cells, and neural stem/progenitor cells. Although significant progress has been made in studying Neuro‐SARS2, much remains to be learned about the neuroinvasive routes (transneuronal and hematogenous) of the virus and the cellular/molecular mechanisms underlying the development/progression of this disease. Future and ongoing studies require the establishment of more clinically relevant and suitable neural cell models using human induced pluripotent stem cells, brain organoids, and postmortem specimens.Citation
This is the peer reviewed version of the following article: Bodnar, B., Patel, K., Ho, W., Luo, J.J., and Hu, W. (2020). Cellular mechanisms underlying neurological/neuropsychiatric manifestations of COVID‐19. Journal of Medical Virology 93, 1983–1998. https://doi.org/10.1002/jmv.26720Citation to related work
WileyHas part
Journal of Medical Virology, Vol. 93, Iss. 4ADA compliance
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http://dx.doi.org/10.34944/dspace/6242