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    Cellular mechanisms underlying neurological/neuropsychiatric manifestations of COVID‐19

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    Name:
    Hu-PostPrint-2020-12.pdf
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    Genre
    Post-print
    Date
    2020-12-10
    Author
    Bodnar, Brittany cc
    Patel, Kena
    Ho, Wenzhe
    Luo, Jin Jun
    Hu, Wenhui cc
    Group
    Center for Metabolic Disease Research (Temple University)
    Department
    Pathology and Laboratory Medicine
    Neurology and Pharmacology
    Subject
    Brain organoids
    COVID‐19
    iPS cells
    Neural cells
    Neuroinvasion
    Neurology
    Neuropsychiatry
    Neurovirulence
    SARS‐CoV‐2
    Permanent link to this record
    http://hdl.handle.net/20.500.12613/6260
    
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    DOI
    https://doi.org/10.1002/jmv.26720
    Abstract
    Patients with severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection manifest mainly respiratory symptoms. However, clinical observations frequently identified neurological symptoms and neuropsychiatric disorders related to COVID‐19 (Neuro‐SARS2). Accumulated robust evidence indicates that Neuro‐SARS2 may play an important role in aggravating the disease severity and mortality. Understanding the neuropathogenesis and cellular mechanisms underlying Neuro‐SARS2 is crucial for both basic research and clinical practice to establish effective strategies for early detection/diagnosis, prevention, and treatment. In this review, we comprehensively examine current evidence of SARS‐CoV‐2 infection in various neural cells including neurons, microglia/macrophages, astrocytes, pericytes/endothelial cells, ependymocytes/choroid epithelial cells, and neural stem/progenitor cells. Although significant progress has been made in studying Neuro‐SARS2, much remains to be learned about the neuroinvasive routes (transneuronal and hematogenous) of the virus and the cellular/molecular mechanisms underlying the development/progression of this disease. Future and ongoing studies require the establishment of more clinically relevant and suitable neural cell models using human induced pluripotent stem cells, brain organoids, and postmortem specimens.
    Citation
    This is the peer reviewed version of the following article: Bodnar, B., Patel, K., Ho, W., Luo, J.J., and Hu, W. (2020). Cellular mechanisms underlying neurological/neuropsychiatric manifestations of COVID‐19. Journal of Medical Virology 93, 1983–1998. https://doi.org/10.1002/jmv.26720
    Citation to related work
    Wiley
    Has part
    Journal of Medical Virology, Vol. 93, Iss. 4
    ADA compliance
    For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
    ae974a485f413a2113503eed53cd6c53
    http://dx.doi.org/10.34944/dspace/6242
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    COVID-19 Research

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