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dc.creatorLo, Alexis L.
dc.creatorTyrell, Richard O.
dc.creatorGolarz, Scott R.
dc.creatorJones, Christine M.
dc.date.accessioned2020-04-20T16:23:04Z
dc.date.available2020-04-20T16:23:04Z
dc.date.issued2019-11-27
dc.identifier.citationLo A, Tyrell R, Golarz S, et al. Reducing Wound Hemorrhage: Use of Bilayer Collagen Matrix in Chronic Myelogenous Leukemia. Plast Reconstr Surg. 2019;7:2532.
dc.identifier.issn2242-1300
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/47
dc.identifier.urihttp://hdl.handle.net/20.500.12613/60
dc.description.abstractSummary: Donor site preparation is a critical step before the application of an autologous split-thickness skin graft (STSG). Comorbidities can lead to complications and graft loss, including that due to hematoma. In this case, a bilayer collagen matrix was used as a temporary wound dressing in a 25-year-old woman with active chronic myelogenous leukemia. She presented with a bleeding diathesis and spontaneous intramuscular and intracompartmental hematomas of the right leg. She experienced ongoing high-volume blood loss from her fasciotomy wounds, requiring wound care to be performed in the operating room under general anesthesia, and requiring multiple blood and platelet transfusions. Instead of immediate STSG, a bilayer collagen matrix was placed to reduce the bleeding and further prepare the wound bed over a 9-week period while she underwent medical optimization. Once stabilized from a hematologic standpoint, STSG was performed with total graft take. Both uncontrolled chronic myelogenous leukemia and its therapy, tyrosine kinase inhibitors, have a risk of hemorrhagic and thrombotic complications. Bilayer collagen matrix serves as an adjunct in the limb salvage algorithm that can reduce transfusion needs whereas a temporary bleeding diathesis is medically corrected before the application of an autologous skin graft.
dc.format.extent3 pages
dc.languageEnglish
dc.language.isoeng
dc.relation.ispartofOpen Access Publishing Fund (OAPF)
dc.relation.haspartPlastic and Reconstructive Surgery - Global Open, Vol. 7, Issue 11
dc.relation.isreferencedbyWolters Kluwer Health, Inc.
dc.rightsAttribution-NonCommercial-NoDerivs CC BY-NC-ND
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleReducing Wound Hemorrhage: Use of Bilayer Collagen Matrix in Chronic Myelogenous Leukemia
dc.typeText
dc.type.genreReport
dc.description.departmentSurgery
dc.relation.doihttps://doi.org/10.1097/GOX.0000000000002532
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.description.schoolcollegeLewis Katz School of Medicine
dc.description.sponsorTemple University Libraries Open Access Publishing Fund, 2019-2020 (Philadelphia, Pa.)
dc.temple.creatorLo, Alexis L.
dc.temple.creatorTyrell, Richard O.
dc.temple.creatorGolarz, Scott R.
dc.temple.creatorJones, Christine M.
refterms.dateFOA2020-04-20T16:23:04Z


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