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dc.creatorEsposito, L
dc.creatorConti, D
dc.creatorAilavajhala, R
dc.creatorKhalil, N
dc.creatorGiordano, A
dc.date.accessioned2021-02-07T17:56:39Z
dc.date.available2021-02-07T17:56:39Z
dc.date.issued2010-01-01
dc.identifier.issn1389-2029
dc.identifier.issn1875-5488
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/6044
dc.identifier.other685IM (isidoc)
dc.identifier.other21532835 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/6062
dc.description.abstractLung cancer is the leading cause of cancer deaths worldwide among both men and women, with more than 1 million deaths annually. Non-small cell lung cancer (NSCLC) accounts for about 80% of all lung cancers. Although recent advances have been made in diagnosis and treatment strategies, the prognosis of NSCLC patients is poor and it is basically due to a lack of early diagnostic tools. However, in the last years genetic and biochemical studies have provided more information about the protein and gene's mutations involved in lung tumors. Additionally, recent proteomic and microRNA's approaches have been introduced to help biomarker discovery. Here we would like to discuss the most recent discoveries in lung cancer pathways, focusing on the genetic and epigenetic factors that play a crucial role in malignant cell proliferation, and how they could be helpful in diagnosis and targeted therapy. © 2010 Bentham Science Publishers Ltd.
dc.format.extent513-518
dc.language.isoen
dc.relation.haspartCurrent Genomics
dc.relation.isreferencedbyBentham Science Publishers Ltd.
dc.rightsCC BY
dc.subjectLung cancer
dc.subjectoncosuppressors
dc.subjectoncogenes
dc.subjectepigenetics of lung cancer
dc.subjectdiagnostic tools for lung cancer
dc.titleLung cancer: Are we up to the challenge?
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.2174/138920210793175903
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.creator.orcidGiordano, Antonio|0000-0002-5959-016X
dc.date.updated2021-02-07T17:56:37Z
refterms.dateFOA2021-02-07T17:56:40Z


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