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dc.creatorTallarida, RJ
dc.creatorMidic, U
dc.creatorLamarre, NS
dc.creatorObradovic, Z
dc.date.accessioned2021-02-04T19:51:07Z
dc.date.available2021-02-04T19:51:07Z
dc.date.issued2013-06-01
dc.identifier.issn0269-4727
dc.identifier.issn1365-2710
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/5945
dc.identifier.other23550787 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/5963
dc.description.abstractWhat is known and Objective Individuals who abuse drugs usually use more than one substance. Toxic consequences of single and multi-drug use are well documented in the Treatment Episodes Data Set that lists drug combinations that result in hospital admissions. Using this list as a guide, we focused our attention on combinations that result in the most hospital admissions and searched the PubMed database with the objective of determining the number of such publications and, in particular, those that used the term synergism in their titles or abstracts. Comment Using the search criteria produced an extensive list of published articles. However, a further intersection of the search terms with the term isobole revealed a surprisingly small number of literature reports. What is new and Conclusion Because the method of isoboles is the most common quantitative method for distinguishing between drug synergism and simple additivity, the small number of investigations that actually employed this quantification suggests that the term synergism is not properly documented in describing the toxicity among abused substances. The possible reasons for this lack of quantification may be related to a misunderstanding of the modelling equations. To help rectify this possible hurdle to understanding and clinical utility, the theory and modelling are discussed here. © 2013 Blackwell Publishing Ltd.
dc.format.extent190-195
dc.language.isoen
dc.relation.haspartJournal of Clinical Pharmacy and Therapeutics
dc.relation.isreferencedbyWiley
dc.subjectabused drugs
dc.subjectdrug combinations
dc.subjectisobole
dc.subjectmulti-drug abuse
dc.subjectsynergy
dc.titleA search for interaction among combinations of drugs of abuse and the use of isobolographic analysis
dc.typeArticle
dc.type.genreReview
dc.type.genreJournal
dc.relation.doi10.1111/jcpt.12055
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.date.updated2021-02-04T19:51:04Z
refterms.dateFOA2021-02-04T19:51:07Z


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