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    The Effect of Inorganic Nanostructured Materials on Neurogenesis

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    Genre
    Thesis/Dissertation
    Date
    2016
    Author
    Chen, Yanshuang
    Advisor
    Suh, Won H.
    Committee member
    Marcinkiewicz, Cezary
    Patil, Chetan Appasaheb
    Pleshko, Nancy
    Department
    Bioengineering
    Subject
    Engineering, Biomedical
    Nanoparticle
    Neurogenesis
    Pc12 Cell
    Permanent link to this record
    http://hdl.handle.net/20.500.12613/595
    
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    DOI
    http://dx.doi.org/10.34944/dspace/577
    Abstract
    Damage and/or loss of functional neurons can lead to detrimental cognitive and paralyzing effects in humans. Prime examples of such negative situations are well documented in patients with Parkinson's and Alzheimer's disease. In recent years, the utilization of neural stem cells and their derivation into neurons have been the focus of many research endeavors. The main reason for this is because neural stem cells are multi-potent and can differentiate into neurons, astrocytes, and oligodendrocytes. The research that will be detailed in this thesis involves the potential use of inorganic nanostructured materials to efficiently deliver bioactive molecules (i.e., retinoic acid, kinase inhibitors) to cells that can modulate the differentiation potential of certain cells into neurons. Specifically, PC12 (derived from rat pheochromocytoma) cells, as a neural model, was treated with select nanostructured materials with and without neuron inducers (molecules and ions) and the results were analyzed via biochemical assays and live-cell fluorescence microscopy. This thesis will include an in depth look into the cytocompatibility of the tested nanostructured materials that include silica nanoparticles, titanate nanotube microspheres, and carbon microparticles.
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