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dc.creatorLorenzo-Redondo, R
dc.creatorFryer, HR
dc.creatorBedford, T
dc.creatorKim, EY
dc.creatorArcher, J
dc.creatorKosakovsky Pond, SL
dc.creatorChung, YS
dc.creatorPenugonda, S
dc.creatorChipman, JG
dc.creatorFletcher, CV
dc.creatorSchacker, TW
dc.creatorMalim, MH
dc.creatorRambaut, A
dc.creatorHaase, AT
dc.creatorMcLean, AR
dc.creatorWolinsky, SM
dc.date.accessioned2021-02-03T16:23:46Z
dc.date.available2021-02-03T16:23:46Z
dc.date.issued2016-02-04
dc.identifier.issn0028-0836
dc.identifier.issn1476-4687
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/5722
dc.identifier.other26814962 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/5740
dc.description.abstract© 2016 Macmillan Publishers Limited. All rights reserved. Lymphoid tissue is a key reservoir established by HIV-1 during acute infection. It is a site associated with viral production, storage of viral particles in immune complexes, and viral persistence. Although combinations of antiretroviral drugs usually suppress viral replication and reduce viral RNA to undetectable levels in blood, it is unclear whether treatment fully suppresses viral replication in lymphoid tissue reservoirs. Here we show that virus evolution and trafficking between tissue compartments continues in patients with undetectable levels of virus in their bloodstream. We present a spatial and dynamic model of persistent viral replication and spread that indicates why the development of drug resistance is not a foregone conclusion under conditions in which drug concentrations are insufficient to completely block virus replication. These data provide new insights into the evolutionary and infection dynamics of the virus population within the host, revealing that HIV-1 can continue to replicate and replenish the viral reservoir despite potent antiretroviral therapy.
dc.format.extent51-56
dc.language.isoen
dc.relation.haspartNature
dc.relation.isreferencedbySpringer Science and Business Media LLC
dc.subjectAnti-HIV Agents
dc.subjectCarrier State
dc.subjectDrug Resistance, Viral
dc.subjectHIV Infections
dc.subjectHIV-1
dc.subjectHaplotypes
dc.subjectHumans
dc.subjectLymph Nodes
dc.subjectModels, Biological
dc.subjectMolecular Sequence Data
dc.subjectPhylogeny
dc.subjectSelection, Genetic
dc.subjectSequence Analysis, DNA
dc.subjectSpatio-Temporal Analysis
dc.subjectTime Factors
dc.subjectViral Load
dc.subjectVirus Replication
dc.titlePersistent HIV-1 replication maintains the tissue reservoir during therapy
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.1038/nature16933
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.creator.orcidPond, Sergei L. Kosakovsky|0000-0003-4817-4029
dc.date.updated2021-02-03T16:23:42Z
refterms.dateFOA2021-02-03T16:23:47Z


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