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    Predicting clinical outcome from reward circuitry function and white matter structure in behaviorally and emotionally dysregulated youth

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    Genre
    Journal Article
    Date
    2016-09-01
    Author
    Bertocci, MA
    Bebko, G
    Versace, A
    Fournier, JC
    Iyengar, S
    Olino, T
    Bonar, L
    Almeida, JRC
    Perlman, SB
    Schirda, C
    Travis, MJ
    Gill, MK
    Diwadkar, VA
    Forbes, EE
    Sunshine, JL
    Holland, SK
    Kowatch, RA
    Birmaher, B
    Axelson, D
    Horwitz, SM
    Frazier, TW
    Arnold, LE
    Fristad, MA
    Youngstrom, EA
    Findling, RL
    Phillips, ML
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    Subject
    Adolescent
    Affective Symptoms
    Bipolar Disorder
    Brain
    Child
    Emotions
    Female
    Forecasting
    Humans
    Longitudinal Studies
    Male
    Parents
    Psychiatric Status Rating Scales
    Reward
    Treatment Outcome
    White Matter
    Show allShow less
    Permanent link to this record
    http://hdl.handle.net/20.500.12613/5735
    
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    DOI
    10.1038/mp.2016.5
    Abstract
    © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Behavioral and emotional dysregulation in childhood may be understood as prodromal to adult psychopathology. Additionally, there is a critical need to identify biomarkers reflecting underlying neuropathological processes that predict clinical/behavioral outcomes in youth. We aimed to identify such biomarkers in youth with behavioral and emotional dysregulation in the Longitudinal Assessment of Manic Symptoms (LAMS) study. We examined neuroimaging measures of function and white matter in the whole brain using 80 youth aged 14.0 (s.d.=2.0) from three clinical sites. Linear regression using the LASSO (Least Absolute Shrinkage and Selection Operator) method for variable selection was used to predict severity of future behavioral and emotional dysregulation measured by the Parent General Behavior Inventory-10 Item Mania Scale (PGBI-10M)) at a mean of 14.2 months follow-up after neuroimaging assessment. Neuroimaging measures, together with near-scan PGBI-10M, a score of manic behaviors, depressive behaviors and sex, explained 28% of the variance in follow-up PGBI-10M. Neuroimaging measures alone, after accounting for other identified predictors, explained ∼1/3 of the explained variance, in follow-up PGBI-10M. Specifically, greater bilateral cingulum length predicted lower PGBI-10M at follow-up. Greater functional connectivity in parietal-subcortical reward circuitry predicted greater PGBI-10M at follow-up. For the first time, data suggest that multimodal neuroimaging measures of underlying neuropathologic processes account for over a third of the explained variance in clinical outcome in a large sample of behaviorally and emotionally dysregulated youth. This may be an important first step toward identifying neurobiological measures with the potential to act as novel targets for early detection and future therapeutic interventions.
    Citation to related work
    Springer Science and Business Media LLC
    Has part
    Molecular Psychiatry
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    ae974a485f413a2113503eed53cd6c53
    http://dx.doi.org/10.34944/dspace/5717
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