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dc.creatorCohn, CA
dc.creatorMueller, S
dc.creatorWimmer, E
dc.creatorLeifer, ND
dc.creatorGreenbaum, S
dc.creatorStrongin, DR
dc.creatorSchoonen, MAA
dc.date.accessioned2021-02-01T22:20:00Z
dc.date.available2021-02-01T22:20:00Z
dc.date.issued2006-04-04
dc.identifier.issn1467-4866
dc.identifier.issn1467-4866
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/5621
dc.identifier.other069QH (isidoc)
dc.identifier.other16759350 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/5639
dc.description.abstractBackground: Pyrite, the most abundant metal sulphide on Earth, is known to spontaneously form hydrogen peroxide when exposed to water. In this study the hypothesis that pyrite-induced hydrogen peroxide is transformed to hydroxyl radicals is tested. Results: Using a combination of electron spin resonance (ESR) spin-trapping techniques and scavenging reactions involving nucleic acids, the formation of hydroxyl radicals in pyrite/aqueous suspensions is demonstrated. The addition of EDTA to pyrite slurries inhibits the hydrogen peroxide-to-hydroxyl radical conversion, but does not inhibit the formation of hydrogen peroxide. Given the stability of EDTA chelation with both ferrous and ferric iron, this suggests that the addition of the EDTA prevents the transformation by chelation of dissolved iron species. Conclusion: While the exact mechanism or mechanisms of the hydrogen peroxide-to-hydroxyl radical conversion cannot be resolved on the basis of the experiments reported in this study, it is clear that the pyrite surface promotes the reaction. The formation of hydroxyl radicals is significant because they react nearly instantaneously with most organic molecules. This suggests that the presence of pyrite in natural, engineered, or physiological aqueous systems may induce the transformation of a wide range of organic molecules. This finding has implications for the role pyrite may play in aquatic environments and raises the question whether inhalation of pyrite dust contributes to the development of lung diseases. © 2006 Cohn et al; licensee BioMed Central Ltd.
dc.format.extent3-
dc.language.isoen
dc.relation.haspartGeochemical Transactions
dc.relation.isreferencedbySpringer Science and Business Media LLC
dc.rightsCC BY
dc.subject0306 Physical Chemistry (incl. Structural)
dc.subject0399 Other Chemical Sciences
dc.titlePyrite-induced hydroxyl radical formation and its effect on nucleic acids
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.1186/1467-4866-7-3
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.creator.orcidStrongin, Daniel R.|0000-0002-1776-5574
dc.date.updated2021-02-01T22:19:57Z
refterms.dateFOA2021-02-01T22:20:00Z


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