Genre
ReviewJournal
Date
2006-05-19Author
Ghafouri, MAmini, S
Khalili, K
Sawaya, BE
Subject
AIDS Dementia ComplexAIDS-Related Opportunistic Infections
Acquired Immunodeficiency Syndrome
Antiretroviral Therapy, Highly Active
Brain
HIV Infections
HIV-1
Humans
Neurons
Prevalence
Permanent link to this record
http://hdl.handle.net/20.500.12613/5634
Metadata
Show full item recordDOI
10.1186/1742-4690-3-28Abstract
Despite the use of highly active antiretroviral therapy (HAART), neuronal cell death remains a problem that is frequently found in the brains of HIV-1-infected patients. HAART has successfully prevented many of the former end-stage complications of AIDS, however, with increased survival times, the prevalence of minor HIV-1 associated cognitive impairment appears to be rising among AIDS patients. Further, HIV-1 associated dementia (HAD) is still prevalent in treated patients as well as attenuated forms of HAD and CNS opportunistic disorders. HIV-associated cognitive impairment correlates with the increased presence in the CNS of activated, though not necessarily HIV-1-infected, microglia and CNS macrophages. This suggests that indirect mechanisms of neuronal injury and loss/death occur in HIV/AIDS as a basis for dementia since neurons are not themselves productively infected by HIV-1. In this review, we discussed the symptoms and causes leading to HAD. Outcome from this review will provide new information regarding mechanisms of neuronal loss in AIDS patients. © 2006 Ghafouri et al; licensee BioMed Central Ltd.Citation to related work
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http://dx.doi.org/10.34944/dspace/5616