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    HIV-1 associated dementia: Symptoms and causes

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    HIV-1 associated dementia symptoms ...
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    Genre
    Review
    Journal
    Date
    2006-05-19
    Author
    Ghafouri, M
    Amini, S
    Khalili, K
    Sawaya, BE
    Subject
    AIDS Dementia Complex
    AIDS-Related Opportunistic Infections
    Acquired Immunodeficiency Syndrome
    Antiretroviral Therapy, Highly Active
    Brain
    HIV Infections
    HIV-1
    Humans
    Neurons
    Prevalence
    Permanent link to this record
    http://hdl.handle.net/20.500.12613/5634
    
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    DOI
    10.1186/1742-4690-3-28
    Abstract
    Despite the use of highly active antiretroviral therapy (HAART), neuronal cell death remains a problem that is frequently found in the brains of HIV-1-infected patients. HAART has successfully prevented many of the former end-stage complications of AIDS, however, with increased survival times, the prevalence of minor HIV-1 associated cognitive impairment appears to be rising among AIDS patients. Further, HIV-1 associated dementia (HAD) is still prevalent in treated patients as well as attenuated forms of HAD and CNS opportunistic disorders. HIV-associated cognitive impairment correlates with the increased presence in the CNS of activated, though not necessarily HIV-1-infected, microglia and CNS macrophages. This suggests that indirect mechanisms of neuronal injury and loss/death occur in HIV/AIDS as a basis for dementia since neurons are not themselves productively infected by HIV-1. In this review, we discussed the symptoms and causes leading to HAD. Outcome from this review will provide new information regarding mechanisms of neuronal loss in AIDS patients. © 2006 Ghafouri et al; licensee BioMed Central Ltd.
    Citation to related work
    Springer Science and Business Media LLC
    Has part
    Retrovirology
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    ae974a485f413a2113503eed53cd6c53
    http://dx.doi.org/10.34944/dspace/5616
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