Coping with viral diversity in HIV vaccine design
dc.creator | Nickle, DC | |
dc.creator | Rolland, M | |
dc.creator | Jensen, MA | |
dc.creator | Kosakovsky Pond, SL | |
dc.creator | Deng, W | |
dc.creator | Seligman, M | |
dc.creator | Heckerman, D | |
dc.creator | Mullins, JI | |
dc.creator | Jojic, N | |
dc.date.accessioned | 2021-02-01T22:11:07Z | |
dc.date.available | 2021-02-01T22:11:07Z | |
dc.date.issued | 2007-04-01 | |
dc.identifier.issn | 1553-734X | |
dc.identifier.issn | 1553-7358 | |
dc.identifier.doi | http://dx.doi.org/10.34944/dspace/5606 | |
dc.identifier.other | 17465674 (pubmed) | |
dc.identifier.uri | http://hdl.handle.net/20.500.12613/5624 | |
dc.description.abstract | The ability of human immunodeficiency virus type 1 (HIV-1) to develop high levels of genetic diversity, and thereby acquire mutations to escape immune pressures, contributes to the difficulties in producing a vaccine. Possibly no single HIV-1 sequence can induce sufficiently broad immunity to protect against a wide variety of infectious strains, or block mutational escape pathways available to the virus after infection. The authors describe the generation of HIV-1 immunogens that minimizes the phylogenetic distance of viral strains throughout the known viral population (the center of tree [COT]) and then extend the COT immunogen by addition of a composite sequence that includes highfrequency variable sites preserved in their native contexts. The resulting COT+ antigens compress the variation found in many independent HIV-1 isolates into lengths suitable for vaccine immunogens. It is possible to capture 62% of the variation found in the Nef protein and 82% of the variation in the Gag protein into immunogens of three gene lengths. The authors put forward immunogen designs that maximize representation of the diverse antigenic features present in a spectrum of HIV-1 strains. These immunogens should elicit immune responses against high-frequency viral strains as well as against most mutant forms of the virus. © 2007 Nickle et al. | |
dc.format.extent | 754-762 | |
dc.language.iso | en | |
dc.relation.haspart | PLoS Computational Biology | |
dc.relation.isreferencedby | Public Library of Science (PLoS) | |
dc.rights | CC BY | |
dc.subject | AIDS Vaccines | |
dc.subject | Antigenic Variation | |
dc.subject | Drug Design | |
dc.subject | Epitope Mapping | |
dc.subject | Gene Products, nef | |
dc.subject | Genetic Variation | |
dc.subject | nef Gene Products, Human Immunodeficiency Virus | |
dc.title | Coping with viral diversity in HIV vaccine design | |
dc.type | Article | |
dc.type.genre | Journal Article | |
dc.relation.doi | 10.1371/journal.pcbi.0030075 | |
dc.ada.note | For Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu | |
dc.creator.orcid | Pond, Sergei L. Kosakovsky|0000-0003-4817-4029 | |
dc.date.updated | 2021-02-01T22:11:04Z | |
refterms.dateFOA | 2021-02-01T22:11:08Z |