Show simple item record

dc.creatorNickle, DC
dc.creatorRolland, M
dc.creatorJensen, MA
dc.creatorKosakovsky Pond, SL
dc.creatorDeng, W
dc.creatorSeligman, M
dc.creatorHeckerman, D
dc.creatorMullins, JI
dc.creatorJojic, N
dc.date.accessioned2021-02-01T22:11:07Z
dc.date.available2021-02-01T22:11:07Z
dc.date.issued2007-04-01
dc.identifier.issn1553-734X
dc.identifier.issn1553-7358
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/5606
dc.identifier.other17465674 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/5624
dc.description.abstractThe ability of human immunodeficiency virus type 1 (HIV-1) to develop high levels of genetic diversity, and thereby acquire mutations to escape immune pressures, contributes to the difficulties in producing a vaccine. Possibly no single HIV-1 sequence can induce sufficiently broad immunity to protect against a wide variety of infectious strains, or block mutational escape pathways available to the virus after infection. The authors describe the generation of HIV-1 immunogens that minimizes the phylogenetic distance of viral strains throughout the known viral population (the center of tree [COT]) and then extend the COT immunogen by addition of a composite sequence that includes highfrequency variable sites preserved in their native contexts. The resulting COT+ antigens compress the variation found in many independent HIV-1 isolates into lengths suitable for vaccine immunogens. It is possible to capture 62% of the variation found in the Nef protein and 82% of the variation in the Gag protein into immunogens of three gene lengths. The authors put forward immunogen designs that maximize representation of the diverse antigenic features present in a spectrum of HIV-1 strains. These immunogens should elicit immune responses against high-frequency viral strains as well as against most mutant forms of the virus. © 2007 Nickle et al.
dc.format.extent754-762
dc.language.isoen
dc.relation.haspartPLoS Computational Biology
dc.relation.isreferencedbyPublic Library of Science (PLoS)
dc.rightsCC BY
dc.subjectAIDS Vaccines
dc.subjectAntigenic Variation
dc.subjectDrug Design
dc.subjectEpitope Mapping
dc.subjectGene Products, nef
dc.subjectGenetic Variation
dc.subjectnef Gene Products, Human Immunodeficiency Virus
dc.titleCoping with viral diversity in HIV vaccine design
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.1371/journal.pcbi.0030075
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.creator.orcidPond, Sergei L. Kosakovsky|0000-0003-4817-4029
dc.date.updated2021-02-01T22:11:04Z
refterms.dateFOA2021-02-01T22:11:08Z


Files in this item

Thumbnail
Name:
Coping with viral diversity in ...
Size:
1.216Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record