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    Nullomers: Really a matter of natural selection?

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    Genre
    Journal Article
    Date
    2007-10-10
    Author
    Acquisti, C
    Poste, G
    Curtiss, D
    Kumar, S
    Subject
    Animals
    Base Sequence
    Cattle
    CpG Islands
    DNA
    Dogs
    Evolution, Molecular
    Genome
    Humans
    Mice
    Molecular Sequence Data
    Mutation
    Pan troglodytes
    Selection, Genetic
    Species Specificity
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    Permanent link to this record
    http://hdl.handle.net/20.500.12613/5617
    
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    DOI
    10.1371/journal.pone.0001022
    Abstract
    Background. Nullomers are short DNA sequences that are absent from the genomes of humans and other species. Assuming that nullomers are the signatures of natural selection against deleterious sequences in humans, the use of nullomers in drug target identification, pesticide development, environmental monitoring, and forensic applications has been envisioned. Results. Here, we show that the hypermutability of CpG dinucleotides, rather than the natural selection against the nullomer sequences, is likely the reason for the phenomenal event of short sequence motifs becoming nullomers. Furthermore, many reported human nullomers differ by only one nucleotide, which reinforces the role of mutation in the evolution of the constellation of nullomers in populations and species. The known nullomers in chimpanzee, cow, dog, and mouse genomes show patterns that are consistent with those seen in humans. Conclusions. The role of mutations, instead of selection, in generating nullomers cast doubt on the utility of nullomers in many envisioned applications, because of their dependence on the role of lethal selection on the origin of nullomers. © 2007 Acquisti et al.
    Citation to related work
    Public Library of Science (PLoS)
    Has part
    PLoS ONE
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    ae974a485f413a2113503eed53cd6c53
    http://dx.doi.org/10.34944/dspace/5599
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