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dc.creatorD'Andrilli, Giuseppina
dc.creatorGiordano, Antonio
dc.creatorBovicelli, Alessandro
dc.date.accessioned2021-02-01T22:02:33Z
dc.date.available2021-02-01T22:02:33Z
dc.date.issued2008-02-14
dc.identifier.issn1874-1894
dc.identifier.issn1874-1894
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/5592
dc.identifier.otherPMC2490600 (pmc)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/5610
dc.description.abstractCancer is frequently considered to be a disease of the cell cycle; alterations in different families of cell cycle regulators cooperate in tumor development. Molecular analysis of human tumors has shown that cell cycle regulators are frequently mutated in human neoplasms, which underscores how important the maintenance of cell cycle commitment is in the prevention of human cancer. The regulatory pathways controlling cell cycle phases include several oncogenes and tumor suppressor genes which display a range of abnormalities with potential usefulness as markers of evolution or treatment response in epithelial ovarian cancer. This review summarizes the current knowledge about these aberrations in malignant tumors of the ovary. We sought to focus our attention on the genes involved in the development of tumors arising from the ovarian epithelium, which are the most common types of ovarian malignancies.
dc.format.extent7-12
dc.language.isoen
dc.relation.haspartThe Open Clinical Cancer Journal
dc.relation.isreferencedbyBentham Science Publishers Ltd.
dc.rightsCC BY
dc.subjectCell cycle deregulation
dc.subjectcancer therapy
dc.subjectovarian carcinoma histotypes
dc.subjectovarian malignancy
dc.titleEpithelial Ovarian Cancer: The Role of Cell Cycle Genes in the Different Histotypes
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.2174/1874189400802010007
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.creator.orcidGiordano, Antonio|0000-0002-5959-016X
dc.date.updated2021-02-01T22:02:30Z
refterms.dateFOA2021-02-01T22:02:33Z


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