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dc.creatorLiberles, DA
dc.creatorDittmar, K
dc.date.accessioned2021-02-01T21:57:26Z
dc.date.available2021-02-01T21:57:26Z
dc.date.issued2008-06-30
dc.identifier.issn1480-9222
dc.identifier.issn1480-9222
dc.identifier.doihttp://dx.doi.org/10.34944/dspace/5587
dc.identifier.other321QY (isidoc)
dc.identifier.other19461954 (pubmed)
dc.identifier.urihttp://hdl.handle.net/20.500.12613/5605
dc.description.abstractGene families are widely used in comparative genomics, molecular evolution, and in systematics. However, they are constructed in different manners, their data analyzed and interpreted differently, with different underlying assumptions, leading to sometimes divergent conclusions. In systematics, concepts like monophyly and the dichotomy between homoplasy and homology have been central to the analysis of phylogenies. We critique the traditional use of such concepts as applied to gene families and give examples of incorrect inferences they may lead to. Operational definitions that have emerged within functional genomics are contrasted with the common formal definitions derived from systematics. Lastly, we question the utility of layers of homology and the meaning of homology at the character state level in the context of sequence evolution. From this, we move forward to present an idealized strategy for characterizing gene family evolution for both systematic and functional purposes, including recent methodological improvements.
dc.format.extent66-73
dc.language.isoen
dc.relation.haspartBiological Procedures Online
dc.relation.isreferencedbySpringer Science and Business Media LLC
dc.subjectgenomics
dc.subjectevolution
dc.subjectmolecular
dc.subjectphylogeny
dc.subjectsequence homology
dc.titleCharacterizing gene family evolution
dc.typeArticle
dc.type.genreJournal Article
dc.relation.doi10.1251/bpo144
dc.ada.noteFor Americans with Disabilities Act (ADA) accommodation, including help with reading this content, please contact scholarshare@temple.edu
dc.creator.orcidLiberles, David A|0000-0003-3487-8826
dc.date.updated2021-02-01T21:57:23Z
refterms.dateFOA2021-02-01T21:57:26Z


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